脓毒症患者血小板功能相关指标检查及临床意义  

Detection of platelet function related indicators in patients with sepsis and their clinical significance

作　　者：但刚[1] 胡莉娜[1] 江忠勇[1] 刘媛[1] 耿雪[1] 谢静[1] 熊杰[1] 

机构地区：[1]成都军区总医院临床实验医学研究与保障中心检验科/高湿医学全军重点实验室,成都610083

出　　处：《检验医学与临床》2015年第9期1191-1192,1195,共3页Laboratory Medicine and Clinic

基　　金：国家高技术研究发展计划(863计划)(2011AA02A111);四川省卫计委科研课题(140007)

摘　　要：目的探讨脓毒症患者血小板聚集功能及P选择素、活化GPⅡb/Ⅲa等血小板活化指标的变化及其意义。方法检测56例脓毒症患者血小板聚集功能及P选择素、活化GPⅡb/Ⅲa的变化。将脓毒症患者分为器官功能不全组和器官功能正常组进行比较分析,并与50例健康对照组进行比较。结果脓毒症患者血小板聚集率显著升高,与健康对照组比较差异有统计学意义(P<0.05),血小板表面表达的P选择素、活化GPⅡb/Ⅲa明显升高,与健康对照组比较差异有统计学意义(P<0.05);器官功能不全组血小板聚集率及血小板表面表达的P选择素、活化GPⅡb/Ⅲa与器官功能正常组比较显著升高,差异有统计学意义(P<0.05)。结论脓毒症患者血小板处于高激活状态,血小板聚集率显著升高,易导致患者发生血栓,血小板聚集率及活化指标可作为判断脏器功能损害的指标之一。Objective To explore the platelet aggregation function and the change of the P selectin ,activated GPⅡb/Ⅲa in the patients with sepsis and their significance .Methods The platelet aggregation function and P selec‐tin ,activated GPⅡb/Ⅲa levels were detected in 56 cases of sepsis .The sepsis patients were divided into the organ dysfunction group and the normal organ function group for conducting the comparative analysis ,and the comparison with 50 healthy controls were performed .Results The platelet aggregation rate in sepsis patients was significantly increased ,showing the statistically significant difference compared with healthy control group（P〈0 .05） ,the levels of P selectin and activated GPⅡb/Ⅲis expressed on platelet surface were significantly increased ,showing the statistical‐ly significant difference compared with healthy control group （P〈0 .05）;the platelet aggregation rate and the levels of P selectin and activated GPⅡb/Ⅲexpressed on platelet surface in the organ dysfunction group were significantly increased compared with the normal organ function group ,the difference was statistically significant（P〈0 .05） .Con‐clusion The platelets in sepsis patients are in high activated state ,and the platelet aggregation rate is significantly in‐creased ,which is easily cause the patients to develop thrombosis .The platelet aggregation rate and activated indexes can be used as the indicators for judging visceral function damage .

关 键 词：脓毒症 血小板聚集 P选择素 GPⅡb/Ⅲa 

分 类 号：R572[医药卫生—消化系统]