环氧合酶-2抑制剂联合顺铂对肺癌的作用机制  

Mechanisms of COX-2 inhibitors combinated with cisplatin for lung cancer

作　　者：魏慧[1] 张卿[1] 

机构地区：[1]内蒙古医科大学附属第一医院呼吸内科,呼和浩特010010

出　　处：《国际肿瘤学杂志》2015年第3期200-202,共3页Journal of International Oncology

基　　金：国家自然科学基金（30560175）;内蒙古医科大学第一附属医院重大科研项目（NYFYZD2012001）

摘　　要：选择性环氧合酶-2（COX-2）抑制剂，可通过抑制环氧合酶、血管内皮生长因子、微血管等，促进肿瘤细胞凋亡和阻断新生血管生长。研究显示，在肺癌的血管和内皮细胞中COX-2高表达，选用COX-2抑制剂辅助化疗，不仅可以直接抑制肿瘤增殖而且可以减轻化疗药物不良反应，提高疗效。探讨选择性COX-2抑制剂联合顺铂对肺癌新生血管的影响及机制，将有希望用于肿瘤临床治疗。Selective COX-2 inhibitors can promote the apoptosis of tumor cells and block the growth of new blood vessels through the inhibition of ring oxidase,vascular endothelial growth factor,microvessel and so on. Research shows that COX-2 is overexpressed in vascular and endothelial cells of lung cancer,select COX-2 inhibitors to adjuvant chemotherapy,not only can directly inhibit the tumor proliferation,but also can reduce the adverse reaction of chemotherapy drugs,and enhance the curative effect. To investigate the effects of selec-tive COX-2 inhibitors and cisplatin in lung cancer angiogenesis and its mechanism,will be a hope for the clini-cal treatment of tumor.

关 键 词：肺肿瘤 血管内皮生长因子类 微血管密度 肿瘤抑制剂 

分 类 号：R734.2[医药卫生—肿瘤]