c-myc 和 CD24在结直肠癌的表达及意义  

Expression and significance of c-myc and CD24 in colorectal cancer

作　　者：陈文军[1] 董崇海[1] 田字彬[2] 

机构地区：[1]青岛大学医学院附属威海医院消化内科,264200 [2]青岛大学医学院附属医院消化内科

出　　处：《国际肿瘤学杂志》2015年第4期255-258,共4页Journal of International Oncology

摘　　要：目的：检测 c-myc 和 CD24在结直肠癌、息肉及正常黏膜中的表达，探讨 c-myc 和 CD24在结直肠癌发生中的作用以及二者之间的关系。方法采用免疫组织化学法对60例结直肠癌、45例大肠腺瘤性息肉、15例大肠增生性息肉、30例正常结直肠黏膜石蜡切片进行 c-myc 和 CD24表达的检测。结果 c-myc 阳性表达率在结直肠癌中为73.3%，明显高于大肠腺瘤性息肉44.4%（χ2=9.0168，P ＜0.01）、大肠增生性息肉13.3%（χ2=18.2159，P ＜0.01）和正常黏膜组织6.7%（χ2=35.5731，P ＜0.01）；CD24阳性表达率在结直肠癌中为76.7%，明显高于大肠增生性息肉6.7%（χ2=25.1330，P ＜0.01）、正常黏膜组织3.3%（χ2=43.1074，P ＜0.01）。c-myc 与结直肠癌的肿瘤部位（χ2=8.3523，P ＜0.01）、淋巴结转移（χ2=4.2751，P ＜0.05）、分化程度（χ2=4.1153，P ＜0.05）和分期（χ2=5.7399， P ＜0.05）有相关性；CD24与肿瘤大小（χ2=9.3336，P ＜0.01）、淋巴结转移（χ2=7.6930，P ＜0.01）、分化程度（χ2=5.8700，P ＜0.05）和分期（χ2=4.4987，P ＜0.05）有相关性。结直肠癌组织中 CD24与c-myc 表达呈正相关（χ2=10.8249，r =0.39，P ＜0.05）。结论 c-myc 与 CD24在结直肠癌中高表达，且与一些临床病理特征有关。在结直肠癌的发生、进展、转移过程中，c-myc 很可能充当了 CD24信号通路的下游靶基因，受 CD24调控。Objective To determine the expression of c-myc and CD24 in colorectal carcinoma,colo-rectal polyp and normal mucosa,and to explore the role and correlation of them in the carcinogenesis of colorec-tal carcinoma. Methods The expression of c-myc and CD24 in colorectal carcinoma（n = 60）,colorectal ade-nomatous polyp（n = 45）,colorectal hyperplastic polyp（n = 15）and the adjacent non-cancerous tissue（n =30）was observed by immunohistochemical assay. Results The positive rate of c-myc in colorectal carcinoma were 73. 3% ,significantly higher than that in colorectal adenomatous polyp 44. 4%（ χ2 = 9. 016 8,P 〈0. 01）,colorectal hyperplastic polyp 13. 3%（χ2 = 18. 215 9,P 〈 0. 01）and adjacent non-cancerous tissue 6. 7%（χ2 = 25. 133 0,P 〈 0. 01）;the positive rate of CD24 in colorectal carcinoma was 76. 7% ,significantly higher than that in colorectal hyperplastic polyp 6. 7%（χ2 = 25. 133 0,P 〈 0. 01）and adjacent non-cancerous tissue 3. 3%（χ2 = 43. 107 4,P 〈 0. 01）. c-myc expression in colon cancer was significantly correlated with cancer site（χ2 = 8. 352 3,P 〈 0. 01）,lymph node metastasis（χ2 = 4. 275 1,P 〈 0. 05）,differentiation （χ2 = 4. 115 3,P 〈 0. 05）and TNM stage（χ2 = 5. 739 9,P 〈 0. 05）. CD24 expression in colon cancer was significantly correlated with cancer size（χ2 = 9. 333 6,P 〈 0. 01）,lymph node metastasis（χ2 = 7. 693 0,P 〈0. 01）,differentiation（χ2 = 5. 870 0,P 〈 0. 05）and TNM stage（χ2 = 4. 498 7,P 〈 0. 05）. There was a pos-itive correlation relationship between CD24 and c-myc in colorectal carcinoma tissue（χ2 = 10. 824 9,r = 0. 39, P 〈 0. 05）. Conclusion The expression of c-myc and CD24 are high in colorectal cancer,having a significant correlation with some of the clinicaopathological features. c-myc is likely to act as a downstream target gene of CD24 signaling pathway,whose expression is probably regulated by CD24 in colorectal carcinoma tissue.

关 键 词：结直肠肿瘤 免疫组织化学 基因 MYC CD24 

分 类 号：R735.34[医药卫生—肿瘤]