腹腔镜与开腹胃癌手术对患者术后免疫功能及细胞因子含量影响的对比研究  

Effect between laparoscopic and open surgery on gastric cancer patients' immune function and cytokine levels

作　　者：邹文凯[1] 

机构地区：[1]成都市第一人民医院普外科,四川成都610017

出　　处：《中国医学装备》2015年第5期46-49,共4页China Medical Equipment

摘　　要：目的:分析腹腔镜与开腹胃癌手术对患者术后免疫功能及细胞因子含量的影响差异。方法:选择114例接受手术治疗的胃癌患者,将其分为接受腹腔镜手术治疗的观察组和接受开腹手术治疗的对照组,比较两组患者的手术一般指标、治疗前后免疫功能T淋巴细胞亚群(CD3+、CD4+及CD4+/CD8+)、细胞因子(TNF-α、IFN-γ)和白细胞介素(IL-6及IL-10)水平差异。结果:1观察组患者接受腹腔镜手术的失血量少于对照组,术后排气时间、下床时间及总住院时间均明显短于对照组,差异有统计学意义(t=5.392,t=4.521,t=5.395,t=4.937;P<0.05);2观察组患者接受腹腔镜手术治疗后的CD3+、CD4+及CD4+/CD8+水平均明显高于对照组,差异有统计学意义(t=4.281,t=5.022,t=4.672;P<0.05);3观察组患者接受腹腔镜手术治疗后的IL-6和IL-10水平低于对照组,而TNF-α及IFN-γ水平明显高于对照组,差异有统计学意义(t=4.294,t=5.138,t=8.362,t=7.173;P<0.05)。结论:腹腔镜手术有助于减少胃癌患者的手术创伤,促进术后康复,提升术后免疫功能并优化细胞因子水平。Objective： To analysis Effect between laparoscopic and open surgery on gastric cancer patients’ immune function and Cytokine levels. Methods：Chosen gastric cancer patients in our hospital patients as research object,divided into observation group with laparoscopic surgery and control group with open operation,compared general index, immune function（CD3^＋, CD4^＋, CD4^＋/CD8^＋） and cytokines（TNF-α, IFN-γ, IL-6, IL-10） level. Results：1）observation group patients’ blood loss was less than control group,postoperative exhaust time,bed time and total length of hospital stay were significantly shorter than control group （t=5.392, t=4.521, t=5.395, t=4.937; P〈0.05）; 2）observation group patients’ CD3^＋, CD4^＋, CD4^＋/CD8^＋ levels were significantly higher than control group patients（t=4.281, t=5.022, t=4.672; P〈0.05）; 3）observation group patients’ IL-6, IL-10 level were lower than control group patients,and TNF-α and level of IFN-γ were significantly higher than control group patients（t=4.294, t=5.138, t=8.362, t=7.173;P〈0.05）. Conclusion：laparoscopic surgery can help reduce the surgical trauma patients with gastric cancer, promote postoperative recovery, enhance the level of postoperative immune function and optimization of cytokines.

关 键 词：胃癌 腹腔镜 免疫功能 细胞因子 

分 类 号：R735.2[医药卫生—肿瘤]