MICA基因多态性与肺癌的相关性研究  

Study on the correlation between polymorphism of MICA gene and lung cancer

作　　者：符小玲[1] 陈纯静[1] 陈恩[1] 陈富超[1] 罗奇志[1] 余平[1] 

机构地区：[1]中南大学基础医学院免疫系,长沙410078

出　　处：《国际免疫学杂志》2015年第3期234-238,共5页International Journal of Immunology

基　　金：国家自然科学基金（81371864）

摘　　要：目的 研究海南汉族人群MICA基因的多态性与肺癌的相关性.方法 采用PCR-SSP和PCR-SBT方法对样本MICA基因的多态性进行检测分析.结果 肺癌患者中有1 1种MICA等位基因被检测出来,MICA＊ A5/010基因频率在肺癌组中明显增高（MICA＊ A5：OR=1.62,95％ CI：1.18～2.23,Pc ＜0.05;MICA ＊010：OR=6.13,95％ CI：3.5～10.75,Pc＜0.000）.结论 MICA＊ A5/010基因可能与肺癌的易感性相关.Objective To study the correlation between polymorphism of MICA gene and lung cancer in Han nationality of Hainan.Methods PCR-SSP and PCR-SBT were used to analyze the gene polymorphism of MICA.Results 11 allelic genes were found in lung cancer patients.The frequency of MICA ＊ A5/ 010 was significantly higher in lung cancer group than that of control group （MICA ＊ A5：OR =1.62,95% CI：1.18-2.23,Pc〈0.05;MICA ＊010：OR=6.13,95%CI：3.5～10.75,Pc〈0.000）.Conclusions MICA ＊ A5/010 allelic gene may be associated with the susceptibility to lung cancer.

关 键 词：MICA 基因 基因多态性 肺癌 

分 类 号：R734.2[医药卫生—肿瘤]