转化生长因子β在脉络膜新生血管形成中的作用  

The role of TGF-β on choroidal neovascularization formation

作　　者：冯一帆[1] 袁非[2] 

机构地区：[1]复旦大学附属中山医院眼科,上海200032 [2]复旦大学癌变与侵袭原理教育部重点实验室

出　　处：《国际眼科纵览》2015年第2期111-116,共6页International Review of Ophthalmology

基　　金：国家自然科学基金（81470637）;癌变与侵袭原理教育部重点实验室开放性课题基金（KLCC12014-1）

摘　　要：转化生长因子-β（transforming growth factor-β,TGF-β）是具有生物活性的多肽,其与脉络膜新生血管形成（choroidal neovascularization,CNV）密切相关.Smad通路为TGF-β行使生物功能的经典通路.TGF-β信号通路在血管系统发育中起着重要作用.TGF-β通过与血管内皮细胞表面的ALK5和ALK1受体结合对其不同活化阶段进行调控,并通过Smad3和p38/MAPK两条信号通路来调控血管平滑肌的分化.CNV形成过程中TGF-β分泌升高,后者在CNV的形成和增生过程中起重要作用.干预TGF-β信号通路有可能成为CNV治疗的新靶点.Transforming growth factor-β （TGF-β）,a polypeptide,has been shown to have biological function and may be closely related to the choroidal neovascularization （CNV） formation.Smads pathway is the classic signaling pathway when TGF-β elicits its pleiotropic effects.TGF-β signaling plays an important role in the development of the vascular system.It can regulate the activation of endothelial cells in different stages by binding to its specific receptors ALK5 and ALK1,and modulate the differentiation of smooth muscle cells through the Smad3 and p38/MAPK signaling pathways.TGF-β secretion is increased during the CNV formation,which play an important role in the CNV process.TGF-β signaling pathway intervention may become a new target for the treatment of CNV.Intervention of TGF-β signal pathway may become a new target for CNV treatment.

关 键 词：脉络膜新生血管 转化生长因子-Β 促血管生成因子 

分 类 号：R774.1[医药卫生—眼科]