虾青素对眼组织保护作用的实验研究及存在的问题  

Experimental study and its problems on the protective effects to ocular tissues of astaxanthin

作　　者：杨明[1] 王志军[1] 

机构地区：[1]中日友好医院眼科,北京100029

出　　处：《国际眼科纵览》2015年第2期140-144,共5页International Review of Ophthalmology

基　　金：中日友好医院重点科研课题（2010-RC-01）

摘　　要：虾青素是一种源于天然生物的类胡萝卜素的含氧衍生物,具有抗氧化、抗炎、抗细胞凋亡,预防心、脑血管疾病及癌症等多种作用,是一类具有一定发展前景的药品和保健食品成份.目前研究表明,虾青素可以透过血-视网膜屏障对眼组织发挥保护作用,已引起研究者的重视.本文针对虾青素在动物实验饲药环节中存在的问题、虾青素的抗氧化作用基础和组织细胞的氧化损伤机制以及在常见眼科疾病中的有关研究现况进行综述.Astaxanthin is a naturally occurred carotenoid which has a strong antioxidant properties,anti-inflammatory effects,resistance to apoptosis,prevention of cardio-cerebrovascular disease and cancer.Studies had revealed that astaxanthin had a good permeability to the blood-retina-barrier to protect the ocular tissues from kinds of damage.This review focused on the merits and demerits of purchasable astaxanthin in experimental animal feeding,free radical peroxidative injury to cells and the antioxidant mechanism of astaxanthin.Moreover,we summarized injury mechanism of oxidative damage of common ocular diseases,and the protective effect of astaxanthin on them.

关 键 词：虾青素 抗氧化作用 氧化损伤 眼部疾病 

分 类 号：R282.710.5[医药卫生—中药学]