非小细胞肺癌病人的术后随访研究  

POSTOPERATIVE FOLLOW-UP STUDIES OF NON-SMALL CELL LUNG CANCER

作　　者：魏起友[1] 韩巴特尔[1] 郭占林[2] 

机构地区：[1]内蒙古医科大学附属人民医院胸外科,内蒙古呼和浩特010010 [2]内蒙古医科大学附属医院胸外科

出　　处：《内蒙古医科大学学报》2015年第2期97-101,107,共6页Journal of Inner Mongolia Medical University

摘　　要：目的：探讨非小细胞肺癌（non-small cell lung cancer,NSCLC）病人术后1-5a生存率,及生存预后因素。方法：回顾分析内蒙古医科大学附属医院胸心外科B区2006-01-2010-12间手术治疗391例NSCLC病人的临床资料,采用门诊、电话、再次入院资料查阅等方法进行术后随访观察。选择性别、年龄、病理类型、肿瘤组织分化程度、病理分期、淋巴结清扫数、淋巴结是否转移、手术方式、术后转移、术后放疗和术后化疗等因素作为观察指标,将各观察指标量化赋值后采用,计算机SPSS 13.0软件进行数据统计,分析术后1-5 a生存率及生存预后因素,采用Kaplan-Meire法进行生存分析;采用log-rank检验和Cox多因素回归模型进行生存预后因素分析。结果：非小细胞肺癌病人术后1至5 a生存率（survival rate,SR）分别为65.7%、57.8%、46.7%、44.3%、44.3%。中位生存时间为43.88mo。单因素分析显示年龄、淋巴结转移、淋巴结清扫数、手术方式、病理分期是术后生存期的影响因素,多因素分析显示年龄、淋巴结转移、病理分期是术后生存的主要影响因素。结论：注重非小细胞肺癌早期手术切除、彻底的淋巴结清扫可延长非小细胞肺癌病人术后的生存期。Objective： The paper discusses postoperative complication,the survival rate from 1 year to 5 year and surviving prognosis factors on non- small cell lung cancer（ NSCLC）. Methods： 391 patients suffering from NSCLC who underwent surgery from January 2006 to December 2010 in our hospital were studied retrospectively. Through follow- up data of out- patient ward,telephone,searching of Analyzing of re- admitted data,so to summarize the incidence of postoperative complication. Possible factors were collected in the data of these patients. The factors included age,pathological type,tumor tissue differentiation,pathological stage,number of dissected lymph nodes,lymph node metastasis,operation mode,postoperative metastasis,postoperative radiotherapy and postoperative chemotherapy,etc.Analyze patients＇ survival rate from 1 to 5 year and survival prognostic factors by using the statistics software of SPSS 13. 0. Kaplan- Meire analyze on survival rate,log- rank law and Cox multi- factor regression model analysis survival of prognostic factors. Results： The incidence of postoperative complications on NSCLC was 8. 95%. The survival rate were 65. 7% 、57. 8% 、46. 7% 、44. 3% 、44. 3% respectively in patients with NSCLC from 1 to 5 year. The median survival time was 43. 88 months. Single factor analysis showed that age,lymph node metastasis,number of dissected lymph nodes,surgical way and pathological stage were the influencing factors after operation of NSCLC. Age,pathological stage,lymph node metastasis were the major influencing factors through multi- factor analysis. Conclusion：Focusing on postoperative management on NSCLC may reduce the incidence of complications after operation. Early operation resection,radical lymph node dissection can prolong survival period after operation of NSCLC.

关 键 词：非小细胞肺癌 围手术期并发症 生存率 生存因素 

分 类 号：R73[医药卫生—肿瘤]