维吾尔族和汉族前列腺癌患者内分泌治疗敏感时间的相关因素分析  

Analysis of correlation factors on the sensitive time of endocrine therapy for Uygur and Han patients with prostate cancer

作　　者：孙涛[1] 拜合提亚.阿扎提 哈木拉提.吐送 王文光[1] 木拉提.热夏提 安恒庆[1] 王玉杰[1] 

机构地区：[1]新疆医科大学第一附属医院泌尿中心,乌鲁木齐830054

出　　处：《新疆医科大学学报》2015年第5期529-532,共4页Journal of Xinjiang Medical University

基　　金：国家自然科学基金(81060210);新疆维吾尔自治区自然科学基金(2010211B22)

摘　　要：目的探讨新疆地区维吾尔族与汉族前列腺癌患者内分泌治疗敏感时间及其影响内分泌治疗敏感时间的临床因素,为新疆地区前列腺癌患者的个体化治疗提供依据。方法将内分泌治疗至进展为去势抵抗性前列腺癌(CRPC)的时间定义为内分泌治疗敏感时间,回顾性分析111例单纯内分泌治疗的维吾尔族和汉族前列腺癌患者的临床资料,建立Cox回归模型,分析各临床因素和内分泌治疗敏感时间的相关关系。结果单因素分析显示,民族(P=0.508)、年龄(P=0.099)、单纯内分泌治疗方式(P=0.399)与内分泌治疗敏感时间无相关性。而初始PSA、临床分期、Gleason评分、PSA最低值、骨转移情况与内分泌治疗敏感时间存在显著相关关系(P<0.05)。多因素分析显示,仅临床分期(P=0.000)和最低PSA值(P=0.000)是前列腺癌患者内分泌治疗敏感时间的主要影响因素。临床分期越高,内分泌治疗后越早出现CRPC。内分泌治疗后PSA能降至0.2 ng/mL及以下的患者较晚发展为CRPC。结论新疆地区维吾尔族与汉族前列腺癌患者内分泌治疗敏感时间无差异,而临床分期与PSA最低值是前列腺癌内分泌治疗敏感时间的独立危险因素。Absract： Objective To explore the sensitive time of endocrine therapy between Xinjiang Uygur and Han patients with prostate cancer and the clinical factors that influence the sensitive time of endocrine therapy,so as to provide the basis of individualized treatment for patients with prostate cancer in the xinjiang region.Methods We defined the time from the beginning of endocrine therapy to developing as castration resistant prostate cancer（CRPC） as the sensitive time of endocrine therapy,in this study,we retrospectively analyzed the clinical data of 111 Uygur and Han patients with prostate cancer who had received endocrine therapy alone,set up the Cox regression model,and analyzed the relationship between various clinical factors and the sensitive time of endocrine therapy.Results Univariate regression analysis revealed that the nation（P = 0.508）,age（P = 0.099）,method of endocrine therapy alone（P = 0.399） had no correlation with the sensitive time of endocrine therapy,initial PSA value,clinical stage,Gleason score,nadir PSA value and bone metastases which existed significant correlation（P〈0.05） with the sensitive time of endocrine therapy.Multivariate regression analysis revealed that only clinical stage（P =0.000） and nadir PSA value（P = 0.000） were the main influencing factors for the sensitive time of endocrinetherapy in patients with prostate cancer.Highor clinical stage lead to earlier CRPC appearance after endocrine theraphy.The patients with prostate cancer conld later grow into CRPC when their RSA value dropped to less than or equal to 0.2 ng/mL after endocrine therapy.Conclusion There is no difference between Uygur and Han patients with prostate cancer in Xinjiang in regand to the sensitive time of evdocrine therapy,but clinical stage and nadir PSA value are independent risk factors for the sensitive time of endocrine therapy in patients with prostate cancer.

关 键 词：前列腺癌 内分泌治疗 民族 

分 类 号：R737.25[医药卫生—肿瘤]