和肽素、血糖与急性脑梗死严重程度的相关性分析  

Correlation analysis of copeptin and blood glucose with the severity of acute cerebral infarction

作　　者：王秀霞[1,2] 常万生[2] 许光霞[2] 

机构地区：[1]滨州医学院,烟台264003 [2]聊城市第二人民医院神经内科

出　　处：《滨州医学院学报》2015年第2期91-93,144,共4页Journal of Binzhou Medical University

摘　　要：目的测定急性脑梗死患者不同时段血清和肽素、空腹血糖水平,探讨和肽素、血糖与NIHSS评分的关系,分析和肽素、血糖与急性脑梗死严重程度的相关性。方法选取发病24h内急性脑梗死患者58例,在发病第1、3、7天抽取空腹肘静脉血,双抗体夹心酶联免疫吸附法测定和肽素,葡萄糖氧化酶法测定空腹血糖,NIHSS评分评估病情的严重程度;同时选择20例健康体检者进行对照比较。结果急性脑梗死患者发病第1、3、7天血清和肽素水平分别为(4.34±1.22)、(4.74±1.71)、(4.49±1.58)pmol/L;空腹血糖水平分别为(6.55±1.03)、(7.04±0.97)、(5.67±0.81)mmol/L。均高于健康体检组和肽素水平(3.64±0.51)pmol/L、空腹血糖水平(5.34±0.91)mmol/L。单因素Logistic回归分析显示,血清和肽素水平、血糖、NIHSS评分、超敏C-反应蛋白、年龄为急性脑梗死患者病情严重程度的影响因素(P<0.05)。受试者工作特征曲线分析结果显示,血清和肽素及空腹血糖对急性脑梗死患者病情严重程度的评估价值与年龄、NIHSS评分、超敏C-反应蛋白(hsCRP)评估价值的比较差异无统计学意义(P>0.05)。NIHSS评分与血清和肽素呈正相关(r=0.246);NIHSS评分与空腹血糖呈正相关(r=0.221);空腹血糖与和肽素呈正相关(r=0.203)(P<0.05)。结论血清和肽素、血糖水平是评估急性脑梗死患者病情严重程度的有效指标。Objective To measure copeptin and fasting blood‐glucose level of patients with acute cerebral infarction ,to dis‐cuss the relationship with copeptin ,blood glucose and NIHSS score ,to investigate the correlation of copeptin and fasting blood- glucose level on the severity of patients with acute cerebrovascular disease .Methods Fifty eight patients with acute cerebral infarction ,whose venous blood were draw in the incidence of 1 ,3 ,7 days .The copeptin was measured with double antibody sandwich enzyme linked immunosorbent assay ,fasting blood glucose was measured with glucose oxidase method ,severity of disease was evaluated by NIHSS ;At the same time ,20 healthy persons were compared .Results Acute cerebral infarction pa‐tients 1 ,3 ,7 days in serum and copeptin levels were （4.34 ± 1.22） 、（4.74 ± 1.71） 、（4.49 ± 1.58）pmol/L ;Blood glucose levels were（6.55 ± 1.03） 、（7.04 ± 0.97） 、（5.67 ± 0.81）mmol/L .The results Were higher than the healthy group and the copeptin levels（3.64 ± 0.51）pmol/L 、（5.34 ± 0.91）mmol/L blood glucose levels .Single factor Logistic regression analysis showed Ser‐um and copeptin level ,blood glucose ,NIHSS score ,high sensitive C reactive protein ,age factors influence the severity of disease in patients with acute cerebral infarction （P〈 0 .05） ,Operating characteristics curve analysis suggested the subjects ,to the as‐sessed value of severity of the illness ,the blood glucose and blood sugar levels in patients with acute cerebral infarction and ser ‐um copeptin had no significant difference in level ,age ,NIHSS score and ultra sensitive value of C reactive protein （P〉 0.05） e‐valuation .NIHSS score was positively correlated with serum and peptide hormone （copeptin） was （r = 0.246） ;NIHSS score and fasting plasma glucose was positively correlated （r= 0.221） ;fasting glucose with and copeptin were positively correlated （r= 0.203） （P〈 0.05） .Conclusion The level of copeptin and blood glucose are t

关 键 词：和肽素 血糖 急性脑梗死 严重程度 

分 类 号：R743.3[医药卫生—神经病学与精神病学]