血清内脂素、CRP水平与脑梗死患者颈动脉粥样硬化斑块稳定性的相关性研究  

Study of the correlation between the level of serum visfatin,CRP and carotid atherosclerotic plaque stability in patients with cerebral infarction

作　　者：常万生[1,2] 王秀霞[2] 许光霞[2] 

机构地区：[1]滨州医学院临床学院,滨州256603 [2]聊城市第二人民医院

出　　处：《滨州医学院学报》2015年第2期94-96,共3页Journal of Binzhou Medical University

摘　　要：目的探讨血清内脂素(visfatin)、C反应蛋白(CRP)水平与颈动脉粥样硬化斑块稳定性的关系,评估预测颈动脉粥样硬化严重程度及缺血性脑血管病事件发生的临床价值。方法选取急性颈内动脉系统脑梗死患者52例(病例组A组),根据颈动脉彩超检查分为稳定斑块组(A1组)22例、不稳定斑块组(A2组)30例;选取年龄及性别构成与病例组相匹配的健康体检者30例(对照组B组)。两组均测定血清visfatin、CRP(超敏)、低密度脂蛋白(LDL)、空腹血糖(FPG)水平。结果血清visfatin、CRP水平A组高于B组,A2组高于A1组。结论血清visfatin、CRP水平增高提示颈动脉粥样硬化斑块不稳定性增加。Objective This study was designed to investigate relationships between the level of serum visfatin ,CRP and sta‐bility of carotid atherosclerosis plaque and evaluate the clinical value of serum visfatin ,CRP to predict the severity of carotid atherosclerosis and ischemic cerebrovasc‐ular disease .Methods The case group（group A ）were 52 cases with cerebral infarc‐tions of acute internal carotid system .Group A was divided into stable plaque group （group A1 ,22 cases） and unstable plaque group （group A2 ,30 cases） according to the carotid artery ultrasonography .30 subjects matched by age and gender who made health examination in the hospital served as controls .The two groups were measured the level of serum visfatin ,CRP ,low den‐sity lipoprotein （LDL） ,fasting plasma glucose （FPG） .Results The level of serum visfatin ,CRP of group A was higher than that of group B and the level was higher of group A 2 than that of group A1 .Conclusion The increasing of serum visfatin ,CRP level suggested the increasing of instability of carotid atherosclerosis plaque .

关 键 词：内脂素 C反应蛋白 脑梗死 颈动脉粥样硬化 

分 类 号：R743.33[医药卫生—神经病学与精神病学]