血管性痴呆患者抗心磷脂抗体与颈动脉内膜厚度及颈动脉狭窄的相关性研究  

Investigation of relations between anti-cardiolipin antibodies and intima membrane thickness,carotid artery stenosis in patients with vascular dementia

作　　者：王茜[1] 徐玉振[2] 亓春花[1] 于爱玲[2] 刘运林[2] 

机构地区：[1]泰安市中心医院中心实验室,山东省271000 [2]泰安市中心医院神经内科,山东省271000

出　　处：《中华脑科疾病与康复杂志（电子版）》2015年第2期11-14,共4页Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）

摘　　要：目的探讨血管性痴呆(VD)患者抗心磷脂抗体(ACA)对颈动脉内膜厚度(IMT)和颈动脉狭窄的影响。方法以酶联免疫吸附法检测32例VD患者(VD组)和31名健康人(对照组)的血清ACA,VD组分为ACA阳性VD组和ACA阴性VD组,三组行颈动脉超声检查,比较三组患者颈动脉IMT及颈动脉狭窄程度。用SPSS 16.0软件进行统计学分析。结果 VD组和对照组ACA的阳性率分别为59.38%、16.13%,与对照组相比,VD组患者ACA阳性率明显偏高(χ2=12.49,P<0.05);ACA阳性VD组、ACA阴性VD组及对照组颈动脉IMT值分别为(1.32±0.12)mm、(1.15±0.10)mm、(0.90±0.07)mm,与ACA阴性组和对照组相比,ACA阳性VD组患者颈动脉IMT明显偏高(t值分别为5.043和15.393,均P<0.05);ACA阳性VD组、ACA阴性VD组及对照组颈动脉狭窄率分别为94.74%、53.85%、12.90%。与ACA阴性组和对照组相比,ACA阳性VD组患者颈动脉狭窄率明显偏高(χ2值分别为6.24和28.78,均P<0.05)。结论 VD患者ACA阳性率偏高,其可能与颈动脉IMT、颈动脉狭窄有关。Objective To explore influence of anticardiolipin（ACA） on intima membrane thickness （IMT） and carotid artery stenosis in patients with vascular dementia（VD）. Methods The content of ACA in blood serum of 32 VD patients （VD group） and 30 average healthy cases （control group） was detected by using ELISA methods, VD group was divided into ACA positive VD group and ACA negative VD group, IMT and carotid artery stenosis degree were detected by ultrasonic. Satistical analysis was performed by SPSS 16. 0. Results The ACA positive rate were 59. 38% ,16. 13% in VD group and control group respectively. The ACA positive rate in VD group was much higher than control greup（χ^2 = 12. 49,P 〈0. 05）. The value of IMT were（ 1.32 ± 0. 12 ） mm, （ 1.15 ± 0. 10 ） mm, （ 0.90 ± 0. 07 ） mm in ACA positive VD group, ACA negative VD group and control group respectively. The value of IMT in ACA positive VD group was much higher than ACA negative group and control group（ t values were 5.043 and 15. 393 respectively, all P 〈 0. 05）. The carotid artery stenosis rate were 94. 74%, 53. 85%, 12. 90% in VD group, cerebral infarction group and control group respectively. The carotid artery stenosis rate in ACA positive VD group was much higher than that in ACA negative VD group and control group（χ^2 values were 6. 24 and 28.78 respectively, all P 〈 0. 05 ）. Conclusion ACA positive rate is higher in VD patients, ACA may be related to IMT, carotid artery stenosis in VD patients.

关 键 词：痴呆 血管性 颈动脉狭窄 抗心磷脂抗体 内膜厚度 

分 类 号：R749.13[医药卫生—神经病学与精神病学]