阿尔茨海默病与抑郁关系的研究进展  

Research progress on the relationship between Alzheimer disease and depression

作　　者：胡竞扬[1] 刘中霖[1] 刘云云[2] 

机构地区：[1]中山大学附属孙逸仙纪念医院神经内科,广州510000 [2]中山大学附属第六医院神经内科,广州510000

出　　处：《中华脑科疾病与康复杂志（电子版）》2015年第2期40-43,共4页Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）

基　　金：广东省自然科学基金(S2013010014550);广州市科技计划项目(2013KP048);西部精神医学协会科研基金(wcpafund2014-5)

摘　　要：阿尔茨海默病(AD)是一种以进行性认知功能障碍和行为损害为特征的中枢神经系统退行性疾病,而临床上有多数AD患者常伴发抑郁。近年来,两种疾病之间的关系受到越来越多的关注,本文就AD与抑郁相互影响作用的假设理论;发生共病的理论机制,包括解剖机制、血管因素机制、炎症机制等;以及针对各种机制提出的治疗方法进行综述,从而为临床治疗AD提供了新思路。Alzheimer＇s disease（AD）is a chronic neurodegenerative disease which characterized by progressive pattern of cognitive and functional impairment, and a lot of AD patients also experienced depression. In recent years, the relationship between AD and depression attracts more and more attentions. This article focused on the relationship of the two diseases, and the mechanism of comorbidity, including dissection,blood vessels, inflammation, as well as the treatments according the different mechanism, which may provide new treatment strategies for AD.

关 键 词：阿尔茨海默病 抑郁症 发病机制 治疗方法 

分 类 号：R749.16[医药卫生—神经病学与精神病学]