溶血磷脂类分子及其受体与多发性硬化的关系  

The relationship between lysophosphatidic molecules and their receptors and multiple sclerosis

作　　者：蒋东晓[1] 连艳芬[1] 詹霞[1] 林勇[1] 吴喜娟[1] 

机构地区：[1]潍坊医学院附属文登中心医院神经内科,山东威海264400

出　　处：《中华脑科疾病与康复杂志（电子版）》2015年第2期52-56,共5页Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）

摘　　要：多发性硬化是一种以中枢神经系统炎性脱髓鞘疾病,临床以多发病灶及病程反复为特点,其病理表现主要是淋巴细胞和巨噬细胞对髓鞘的破坏及继发性轴索损害。溶血磷脂酸分子是调节细胞生存与凋亡的重要信号分子,与肿瘤、动脉粥样硬化及缺血性心脑血管病等病理过程有关。近年来研究表明,溶血磷脂类分子不仅参与各种炎性细胞因子的产生,而且同炎性细胞的浸润密切相关,对中枢神经系统的髓鞘脱失、轴索损害产生重要影响,本文就溶血磷脂类分子与多发性硬化关系的研究进展作一综述。Multiple sclerosis is an inflammatory demyelinating diseases of central nervous system, with multiple lesions and clinical course of repeated for characteristics, the pathology shows the damage of lymphocytes and macrophages to myelin and secondary axonal damage. Lysophosphatidic molecules is an important signal molecule in regulation of cell survival and apoptosis, with relationship to the pathological processes of tumor,atherosclerosis and ischemic cardio cerebral vascular diseases. Recent studies show that lysophospholipids molecules not only participate in the production of a variety of inflammatory cytokines, but also have closely relation to the infiltration of inflammatory cells, and have an important impact on the central nervous system demyelination, axonal damage. This article reviewed the research progress of relationship of lysophospholipid molecule and multiple sclerosis.

关 键 词：多发性硬化 溶血磷脂酸 酸性磷脂 

分 类 号：R744.51[医药卫生—神经病学与精神病学]