急性脑梗死患者糖代谢异常与血尿酸水平的相关性研究  

Study on the Relationship Between Glycometabolism Abnormalities and Serum Uric Acid Levels in Patients with Acute Ischemic Stroke

作　　者：田沈[1] 李静[1] 王君梅[1] 甘秀红 张东圆[1] 

机构地区：[1]中国医科大学附属第四医院神经内科,辽宁沈阳110032

出　　处：《中国血液流变学杂志》2014年第4期482-484,共3页Chinese Journal of Hemorheology

基　　金：沈阳市科学技术项目（F12-193-9-34）

摘　　要：目的：分析急性脑梗死患者糖代谢异常与血尿酸水平的相关性，探讨急性脑梗死的危险因素。方法连续纳入急性脑梗死患者421例，根据化验结果分为2组：糖代谢异常组（糖尿病、糖调节受损）172例、正常血糖组249例。对2组血尿酸、血脂水平进行比较；在糖代谢异常组根据糖化血红蛋白水平分成4组分别进行血尿酸、血脂的比较。结果糖代谢异常组血尿酸、血脂水平均高于正常血糖组；血尿酸水平随着糖化血红蛋白水平的升高而逐渐升高。结论急性脑梗死患者血尿酸水平随着血糖的升高而升高；糖代谢异常及高尿酸均为急性脑梗死独立危险因素。Objective To analyze the relationship between glycometabolism abnormalities and serum uric acid levels in the patients with acute ischemic stroke, and to explore the associated risk factors of acute ischemic stroke.Methods 421 patients with acute ischemic stroke were recruited consecutively who were divided into two groups according to the results of blood test： 172 patients with abnormal glycometabolism （diabetes and impaired glucose regulation） in one group and 249 patients with normal plasma glucose in the other group. The serum uric acid levels and blood lipid levels between two groups were compared. Meanwhile, the group of abnormal glycometabolism was divided into four subgroups based on the different levels of HbA1c. We aimed to evaluate the association of serum uric acid levels, and blood lipid levels in these subgroups.Results Both of the serum uric acid and blood lipid levels in abnormal glucose metabolism were higher than in normal plasma glucose group. Furthermore, the levels of serum uric acid increased with HbA1c levels.Conclusion In the patients with acute ischemic stroke, serum uric acid levels rise with serum glucose levels; glycometabolism abnormalities and hyperuricaemia are both of the independent risk factors for acute ischemic stroke.

关 键 词：糖代谢异常 血尿酸 急性脑梗死 

分 类 号：R743.3[医药卫生—神经病学与精神病学]