盐酸米诺环素辅助一站式全口龈下刮治和根面平整术治疗中重度慢性牙周炎的疗效观察  

Clinical effect observation of minocycline hydrochloride ointment on moderate or severe chronic periodontitis as adjunct therapy in full-mouth periodontal scaling and root planning

作　　者：胡滨青[1] 杨淑银[2] 岳二丽[2] 

机构地区：[1]郑州大学第二附属医院药剂科,郑州市450000 [2]郑州大学口腔医学院牙周科,郑州市450052

出　　处：《临床合理用药杂志》2015年第14期34-35,44,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的通过观察盐酸米诺环素(MHO)辅助一站式全口龈下刮治和根面平整术(FM-SRP治疗)和分象限全口龈下刮治和根面平整术(Q-SRP)治疗中重度慢性牙周炎效果,探讨局部应用药物辅助治疗的必要性和最佳治疗方案的选择。方法将80例中重度慢性牙周炎患者随机分为4组:FM-SRP-MHO组和Q-SRP-MHO组SRP同时均辅助使用盐酸米诺环素;FM-SRP组和Q-SRP组仅SRP,不辅助用药。分别在基线、3个月和6个月时,检测菌斑指数(PI)、牙龈指数(GI)、探诊出血(BOP)、探诊深度(PD)及附着丧失(AL)的变化及患者的术后反应。所得结果分别进行秩和检验(PI,GI)、t检验(PD、AL)和χ2检验(BOP)。结果 4组患者治疗前后PD、BOP、AL各值相比有统计学意义(P<0.01);其中FM-SRP-MHO组和Q-SRP-MHO组分别与FM-SRP和Q-SRP相比PD、BOP、AL各值相比有统计学意义(P<0.01)。结论治疗中重度慢性牙周炎临床效果FM-SRP-MHO法优于FM-SRP,Q-SRP-MHO法优于QSRP法,表明SRP的同时局部辅以盐酸米诺环素是慢性牙周炎较好的治疗方法。Objective To explore the necessity of the adjuvant treatment of local drugs application and the best treat- ment option, though observe the clinical effects of full-mouth periodontal scaling and root planning （FM-SRP） and quadrant full mouth periodontal scaling and root planning （Q-SRP） with local delivery of antibiotics （ minocycline hydrochloride ointment, MHO） as adjunct therapy in the treatment of moderate or severe chronic periodontitis. Methods 80 patients with moderately severe chronic periodontitis were randomly divided into 4 groups. FM-SRP-MHO group received full-mouth scaling and root planning combined with MHO, Q-SRP-MHO group received quadrant scaling and root planning combined with MHO. FMSRP group only received full-mouth scaling and root planning. Q-SRP group received quadrant scaling and root planning only. Clinical parameters of plaque index （ PI）, gingival index （GI） , bleeding on probing （ BOP）, probing depth （ PD ） and attachment loss （AL） were collected at baseline ,3 and 6 months after treatment, as well as the postoperative reaction. The data were analyzed by rank sum test （PI,GI） ,t test （PD,AL） and Chi square test （BOP） ,respectively. Results When compared with the baseline, all of therapies resulted in significant improvements in all clinical parameters at the end of 3 and 6 months （ P 〈 0.01 ）. There were significant differences of PD, GI and AL between 2 experimental groups and 2 control groups （ P 〈 0. 01 ）. Conclusion The clinical effect of FM-SRP combined with MHO is better than FM-SRP alone, and the clinical effect of Q- SRP combined with MHO is better than Q-SRP alone in the treatment of moderate or severe chronic periodontitis. The local delivery of antibiotics is effective and secure for treating chronic periodontitis with MHO as adjunct therapy.

关 键 词：慢性牙周炎 龈下刮治 根面平整术 盐酸米诺环素 

分 类 号：R781.4[医药卫生—口腔医学]