重组人粒细胞巨噬细胞集落刺激因子联合重组牛碱性成纤维细胞生长因子治疗化疗性口腔溃疡的临床观察  

Analysis of clinical effect of recombinant human granulocyte-macrophage colony-stimulating factor combined with recombinant bovine basic fibroblast growth factor in the treatment of oral ulcer caused by chemotherapy

作　　者：孙旋[1] 杜秀平[1] 韩正祥[1] 

机构地区：[1]徐州医学院附属医院肿瘤科,221000

出　　处：《肿瘤研究与临床》2015年第4期263-265,共3页Cancer Research and Clinic

摘　　要：目的 观察重组人粒细胞巨噬细胞集落刺激因子（rhGM-CSF）联合重组牛碱性成纤维细胞生长因子（rb-bFGF）治疗化疗性口腔溃疡的效果.方法 将108例肿瘤科化疗引起口腔溃疡的患者按完全随机设计/成组设计分成两组,对照组54例先给予西地碘片含服,之后给予庆大霉素、地塞米松、2％利多卡因、0.9％氯化钠溶液制成的雾化剂,3次/d;治疗组54例先给予rhGM-CSF、地塞米松、0.9％氯化钠溶液配成的溶液含漱,再给予rb-bFGF喷涂溃疡面,3次/d.结果 治疗组有效率为96.30％（52/54）,优于对照组的64.81％（35/54）,两组比较差异有统计学意义（x2=17.08,P＜ 0.05）.结论 rhGM-CSF联合rb-bFGF治疗化疗性口腔溃疡疗效甚佳.Objective To investigate the effect of recombinant human granulocyte-macrophage colony-stimulating factor （rhGM-CSF） combined with recombinant bovine basic fibroblast growth factor （rb-bFGF） in the treatment of oral ulcer caused by chemotherapy.Methods 108 patients of oral ulcer caused by chemotherapy were randomly divided into two groups.54 cases in the control group were treated with cydiodine buccal tablets at first,then received the aerosol treatment which was prepared by mixing gentamicin,dexamethasone,2 ％ lidocaine and physiologic saline,three times per day.54 cases in the treatment group firstly received the gargle which was prepared by mixing rhGM-CSF,dexamethasone and physiologic saline,then were treated with rb-bFGF by spraying on the oral ulcer surface,three times per day.Results The effective rate of the treatment group was 96.30 ％ （52/54）,which was significantly higher than that of the control group [64.81％ （35/54）],there was a significant difference between the two groups （x2 =17.08,P ＜ 0.05）.Conclusion The effect of rhGM-CSF combined with rb-bFGF in the treatment of oral ulcer caused by chemotherapy is very significant.

关 键 词：重组人粒细胞巨噬细胞刺激因子 重组牛碱性成纤维细胞生长因子 化疗性口腔溃疡 

分 类 号：R730.5[医药卫生—肿瘤]