Oct-4在肿瘤干细胞中的研究进展  

Research progress of Oct-4 in cancer stem cells

作　　者：包建涛[1] 颉玉胜[2] 廖辉[1] 

机构地区：[1]兰州军区兰州总医院安宁分院耳鼻喉科,730070 [2]兰州军区兰州总医院安宁分院皮肤美容科,730070

出　　处：《肿瘤研究与临床》2015年第4期283-286,共4页Cancer Research and Clinic

摘　　要：干细胞（SC）是一类具有潜在自我更新和分化能力的初始细胞,在一定条件下,它可以增殖并分化为多种功能细胞.核蛋白Oct-4、Nanog和Sox2是3个主要转录调节因子,在维持SC多能特性、抑制SC分化的过程中发挥着核心作用.肿瘤干细胞（CSC）假说认为,在肿瘤组织内很可能也存在着具有不断增殖和分化能力的SC,即CSC,正是CSC导致了肿瘤侵袭生长、转移和对治疗的抗性.确定SC的标志物成为当前肿瘤领域研究的重要方向,而将维持SC的核心调控分子Oct-4、Nanog、Sox2引入CSC领域无疑是目前研究的前沿.现对Oct-4在CSC中的研究进展进行综述.Stem cell （SC） is a class of initial cells with potential self renewal and differentiation ability.Under certain conditions,it can proliferate and differentiate into various functional ceils.Nucleoprotein Oct-4,Nanog and Sox2 are three major transcription factors,which play central roles in maintaining the pluripotent characteristics and inhibiting SC differentiation.Cancer stem cell（CSC） theory supposed that there is also existing SC-CSC possessing potential self renewal and differentiation abilities in tumor tissues.It is the SC properties of CSC that result in tumor＇s invasive growth,metastasis and resistance to treatment.Therefore,looking for CSC and determining their markers become an important direction for cancer research.And the introduction of Oct-4,Nanog and Sox2 into CSC research field is undoubtedly the most exciting forefront.

关 键 词：OCT-4 肿瘤干细胞 

分 类 号：R730.2[医药卫生—肿瘤]