血清巨噬细胞移动抑制因子与急性脑梗死的相关性研究  

Correlation Between Serum Macrophage Migration Inhibitory Factor and Acute Cerebral Infarction

作　　者：于治华[1] 高连波[1] 高红华[1] 杨艳[1] 田沈[1] 曹云鹏[2] 

机构地区：[1]中国医科大学附属第四医院神经内科,辽宁沈阳110032 [2]中国医科大学附属第一医院神经内科,辽宁沈阳110001

出　　处：《医学临床研究》2015年第4期625-628,共4页Journal of Clinical Research

基　　金：国家自然科学基金（81471198）

摘　　要：【目的】探讨急性脑梗死（ACI）患者血清巨噬细胞移动抑制因子（MIF）水平与病情严重程度和短期预后的关系。【方法】选择ACI患者106例，采用美国国立卫生研究院卒中量表NIHSS评分分为轻型脑梗死组（A组，NIHSS评分＜4分）40例、中型脑梗死组（B组，NIHSS评分4～15分）38例、重型脑梗死组（C组， NIHSS评分＞15分）28例。同期住院48例有动脉粥样硬化（Atherosclerosis ，AS）危险因素非急性脑梗死患者为对照组（D组）。酶联免疫吸附法（ELISA ）测定各组患者血清中M IF水平，对ACI患者随访，评估90 d改良Ranking量表（ mRS）评分，进行统计学分析。【结果】A、B、C与D组血清MIF存在差异，数值上A组、B组、C组大于D组，具有统计学意义（ P ＜0．05）。相关性分析，MIF与高敏C反应蛋白（hs‐CRP）、同型半胱氨酸（Hcy）、白细胞（WBC）、中性粒细胞百分比（NEUT％）呈正相关，与单核细胞百分比（MONO％）呈负相关。Logistic回归分析，收缩压（SBP ）、M IF、低密度脂蛋白胆固醇（LDL‐C ）、Hcy、WBC水平与患者90 d的mRS评分呈正相关。【结论】急性脑梗死患者血清 M IF水平升高，与病情严重程度及90 d预后相关，说明M IF可能参与了ACI的炎症反应过程。[Objective]To explore the correlation between serum macrophage migration factor （MIF） and the severity and short‐term prognosis of patients with acute cerebral infarction （ACI） .[Methods] A total of 106 ACI patients were recruited and divided into mild （A ,n=40 ,score 〈4） ,moderate （B ,n=38 ,score 4～15） and severe groups （C ,n =28 ,score 〉15） according to the criteria of National Institute of Health stroke scale （NIHSS） .Meanwhile 40 non‐acute cerebral infarction inpatients with atherosclerosis were selected as control group （D） .The serum level of MIF was detected by enzyme‐linked immunosorbent assay （ELISA） . During follow‐ups ,the 90‐day modified Rankin scale （mRS） was evaluated .[Results] The serum levels of MIF in groups A ,B and C were greater than that of group D and the differences were statistically significant （ P 〈0 .05） .Positive correlations existed between MIF and high sensitivity‐C‐reactive protein （hs‐CRP） ,ho‐mocysteine （Hcy ） and white blood cell （WBC ） separately while negative correlation between MIF and NEUT% and MONO% .Logistic analysis showed the levels of systolic blood pressure （SBP） ,MIF ,low‐den‐sity lipoprotein‐cholesterol （LDL‐C） , Hcy and WBC were associated with the 90‐day evaluation of mRS .[Conclusion]As compared with control group ,an elevated serum level of MIF is correlated with the severity and 90‐day prognosis of ACI .And it suggests a probable involvement of MIF in inflammatory reaction process of ACI .

关 键 词：巨噬细胞游走抑制因子/血液 脑梗死 急性病 损伤严重度评分 

分 类 号：R743.33[医药卫生—神经病学与精神病学]