血清炎性细胞因子纤维蛋白原、白细胞介素-6及肿瘤坏死因子-α在进展性脑梗死中的临床意义  

Correlation between serum levels of inflammatory cytokine interleukin- 6( IL- 6),fibrinogen and tumor necrosis factor- α and development and progression of cerebral infarction

作　　者：尹雪[1] 段伟[2] 董智慧[2] 罗德欣[2] 

机构地区：[1]哈尔滨医科大学第五临床医学院神经内科 [2]哈尔滨医科大学附属第五医院神经内科,黑龙江大庆163316

出　　处：《临床和实验医学杂志》2015年第9期726-728,共3页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和纤维蛋白原(Fib)在进展性脑梗死中临床意义。方法将2013年12月至2014年12月住院治疗的41例非进展性脑梗死患者作为非进展组,45例进展性脑梗死患者作为进展组,另选取同期50例体检健康者作为健康对照组。于患者入院后第1、3、5、7、14 d时检测其白细胞介素6(IL-6)、肿瘤坏死因子(TNF-α)和纤维蛋白原(Fib)水平并与健康对照组进行比较,结果进行统计学分析。结果脑梗死患者血清IL-6、TNF-α与Fib水平分别为(310.83±21.28)pg/ml、(2.26±0.24)pg/ml、(4.18±0.59)g/L,与健康对照组进行比较均有显著性增加,差异具有统计学意义(P<0.05);进展性脑梗死患者入院第1、3、5、7、14 d时检测其IL-6、TNF-α与Fib水平均较非进展性脑梗死患者有显著性增加,且差异存在统计学意义(P<0.05)。结论脑梗死患者血清IL-6、TNF-α与Fib水平均较健康对照组有显著升高,且进展性脑梗死患者发展过程中各项指标均高于非进展性脑梗死患者,具有较好的临床预测价值。Objective To analyze the correlation between serum levels of inflammatory cytokine interleukin - 6,tumor necrosis factor -α（TNF - α）and fibrinogen（Fib）,development,progression of cerebral infarction. Methods 41 cases of hospitalized patients with non pro-gressive cerebral infarction in December 2013 to December 2014 were as non progress group,45 cases of patients with progressive cerebral infarc-tion were selected as the progress group,the other 50 cases of healthy persons as healthy control group,to detect and compare the IL - 6,TNF -αand Fib levels after 1,3,5,7,14 d of hospital in the patients and control group. Results The serum IL - 6,TNF - α and Fib levels in pa-tients with cerebral infarction were（310. 83 ± 21. 28）pg/ ml,（2. 26 ± 0. 24）pg/ ml,（4. 18 ± 0. 59）g/ L,which significantly increased than the healthy control group,with significant difference（ P 〈 0. 05）. The IL - 6,TNF - α and Fib levels in the progressive cerebral infarction patients after 1,3,5,7,14 d admitted to hospital increased significantly than the non progressive cerebral infarction patients. The difference was signifi-cant（ P 〈 0. 05）. Conclusion The serum IL - 6,TNF - α and Fib levels in the cerebral infarction patients increased significantly when com-pared with healthy control group. The indicators in the progressive cerebral infarction patients are higher than the patients with non progressive cer-ebral infarction,with clinical better predictive value.

关 键 词：进展性脑梗死 白细胞介素-6 肿瘤坏死因子-Α 纤维蛋白原 

分 类 号：R743.3[医药卫生—神经病学与精神病学]