非酒精性脂肪性肝病患者瘦素水平与胆石症及胰岛素抵抗关系的研究  

Leptin levels in patients with NAFLD and its relationship with cholelithiasis and insulin resistance

作　　者：郁海燕 

机构地区：[1]上海市闸北区市北医院消化科,上海200435

出　　处：《临床和实验医学杂志》2015年第9期731-733,共3页Journal of Clinical and Experimental Medicine

基　　金：上海市闸北区卫生局课题(编号:2011YB03)

摘　　要：目的探讨非酒精性脂肪性肝病(NAFLD)患者瘦素水平与胆石症及胰岛素抵抗关系。方法选择NAFLD伴胆石症患者共62例(研究组)和不伴胆石症患者共60例(对照组)。检测两组血清瘦素、空腹血糖(FBG)、空腹胰岛素(FINS)水平;计算胰岛素敏感指数(ISI)、胰岛素抵抗指数(HOMA-IR),观察瘦素水平与其他指标的相关性。结果研究组胰岛素水平、HOMA-IR、瘦素水平显著高于对照组。瘦素与HOMA-IR、FINS、FBG等存在较好的相关性。瘦素(OR=2.763)和胰岛素抵抗(OR=1.934)是NAFLD合并胆石症的最重要的预测指标。结论 NAFLD患者血清瘦素水平与胰岛素抵抗密切相关,是反映胆石症形成的一个预测指标。Objective To investigate the leptin levels in patients with non - alcoholic fatty liver disease（NAFLD）and its relationship with cholelithiasis and insulin resistance. Methods A total of 62 patients with NAFLD and cholelithiasis（study group）and 60 NAFLD patients without cholelithiasis（control group）were collected. Serum leptin,fasting blood glucose（FBG）,fasting insulin（FINS）levels were detected;insulin sensitivity index（ISI）and insulin resistance index（HOMA - IR）were calculated. The relation between leptin and other parameters were observed. Results Insulin,HOMA - IR and leptin levels in study group were significantly higher than control group. There was a good correlation between leptin and HOMA - IR,FINS and FBG. Leptin（OR = 2. 763）and insulin resistance（OR = 1. 934）were the most important predictor of NAFLD and cholelithiasis. Conclusion Serum leptin levels in patients with NAFLD and cholelithiasis are closely related to insulin resistance, which is a predictive indicator of cholelithiasis formation.

关 键 词：非酒精性脂肪性肝病 瘦素 胆石症 胰岛素抵抗 

分 类 号：R575[医药卫生—消化系统]