胃食管反流合并功能性肠病患者的临床特点研究  

The study of clinical features of gastrooesophageal reflux disease combined with functional bowel diseases

作　　者：何子彬[1] 杨清强[1] 周骥[1] 何元清[1] 

机构地区：[1]四川省广元市第三人民医院消化内科,四川广元628000

出　　处：《安徽医药》2015年第5期929-931,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：探讨胃食管反流病(GERD)合并功能性肠病的发生情况及其相关因素。方法 2010年1月—2014年6月该院消化科门诊收治具有典型反流症状的患者254例,采用反流性疾病问卷(RDQ)对其典型反流症状评分,RDQ评分≥12分诊断GERD,并结合胃镜检查结果和对质子泵抑制剂治疗的反应将GERD患者分为反流性食管炎(RE)和非糜烂性反流病(NERD)。按照罗马Ⅲ诊断标准筛选患者是否患有功能性肠道疾病(FBD)。结果诊断为GERD的患者162例,肠易激综合征(IBS)56例,功能性腹泻(FD)32例,功能型便秘(FC)22例,功能性腹胀(FB)5例,功能性肠病患者共115例。GERD与IBS、FD、FC、FB的重叠率均高于对照组;与对照组相比,其中与IBS重叠率有显著统计学差异(P<0.05),FD、FC、FB的重叠率无显著统计学差异(P>0.05)。与RE相比,NERD合并FBD的比例较高,但差异无统计学意义(P>0.05)。GERD患者的RQD评分与发生功能性肠道疾病的重叠有相关性(P<0.05)。结论 GERD与IBS、FD、FC、FB均有一定的重叠,其中IBS及FD的重叠率最高。GERD患者的RQD评分越高,与功能性肠道疾病发生重叠的几率越大。Objective To investigate incidence of GERD （gastrooesophageal reflux disease,GERD）combined with functional bowel diseases and analyze the factors related to such overlap.Methods A total of 254 outpatients treated at our hospital from January 2010 to June 2014 due to typical reflux symptoms were included in the study.GERD was diagnosed when the score（Sc）of reflux diagnostic questionnaire （RDQ）was greater than or equal to 12.Reflux esophagitis （RE）and non-erosive reflux disease （NERD）were differ-entiated according to RQD scores,endoscopic diagnosis and response to proton pump inhibitor therapy.Functional bowel diseases （FBD）was diagnosed based on RomeⅢ criteria.Results 162 patients were diagnosed with GERD.A total of 1 15 cases of FBD were diagnosed,including 56 irritable bowel disease,32 functional diarrhea,22 functional constipation and 5 functional bloating.The preva-lences of IBS,FD,FC and FB in GERD patients were higher than those in control patients.The incidence of IBS in GERD patients was significantly higher than that in control patients （P 〈0.05）,though no significant difference was observed in the prevalences of FD, FC and FB between the two groups（P 〉0.05）.Compared with RE,NERD had higher rate of overlapping with FBD,but the difference was not statistically significant （P 〉0.05）.GERD symptom score was significantly related with the overlap of GERD and functional bowel disease （P 〈0.05）.Conclusions IBS,FD,FC and FB in GERD patients are more prevalent than those in the general popula-tion,and the prevalence of IBS in GERD patients is significantly higher than that in the general population.GERD symptom score has significant relation with the overlap of GERD and functional bowel diseases.

关 键 词：胃食管反流 临床特点 功能性肠道疾病 

分 类 号：R57[医药卫生—消化系统]