卵巢肿瘤相关的神经系统副肿瘤综合征的早期诊断及治疗  

Identification and Management of Paraneoplastic Neurological Syndromes Associated with Ovarian Cancers

作　　者：刘淑娟[1] 蔡国青[1] 张潍[1] 邹伟[1] 王建[1] 

机构地区：[1]第四军医大学西京医院妇产科,陕西西安710032

出　　处：《医学与哲学（B）》2015年第4期55-56,F0003,共3页Medicine & Philosophy(B)

摘　　要：神经系统副肿瘤综合征(PNS)是由潜在的新发肿瘤诱发的一系列神经功能缺损与异常。PNS的表现可早于原发肿瘤的症状,故可作为预警信号帮助卵巢肿瘤的早期诊断。伴有PNS的肿瘤其恶性程度和转移倾向都低于不伴有PNS者,因此可被视作机体的抗肿瘤反应。副肿瘤性小脑变性和抗NMDAR脑炎是最常见的卵巢肿瘤相关的PNS。对原发肿瘤的早期切除是治疗PNS最有效的手段并可显著改善患者的预后。如何在工作中认识PNS的相关表现,并尽早对尚未发现的原发肿瘤进行筛查,以及积极治疗肿瘤和其相关的PNS?本文对此问题作以讨论,以期指导临床工作。Paraneoplastic neurological syndrome （PNS） is defined as a group of neurological deficits triggered by newly onset underlying tumor .The onset of PNS can precede clinical presentations of primary cancers and thus can call attention to screening and early diagnosis of ovarian cancers .The malignancy and metastatic potency of tumors with PNS tend to be less advanced than those without PNS ,indicating that PNS may be considered as an antitumor response of human body . Paraneoplastic cerebellar degeneration （PCD） and anti‐N‐methyl‐D‐aspartate receptor （NMDAR） encephalitis are two most common PNS associated with ovarian cancers .Surgical resection of primary tumor is the most effective treatment for PNS and improves prognosis significantly .However ,it remains a challenge for the physicians to identify and correctly diagnose PNS in practice ,which in turn lead to screening for primary tumor and management of both PNS and tumor .This manuscript aimed to discuss the related issues and provide guidance for physicians to follow .

关 键 词：副肿瘤综合征 卵巢肿瘤 肿瘤神经抗体 

分 类 号：R737.31[医药卫生—肿瘤]