3种肿瘤标志物检测在乳腺癌术后随访中的价值  

Value of three tumor markers detection in the follow-up of breast cancer

作　　者：石文[1] 邱峰[1] 林莉[1] 尚陈宇 潘婉仪[1] 卢燕君[1] 徐建华[1] 

机构地区：[1]广东省中医院检验科,广州510105

出　　处：《检验医学与临床》2015年第10期1356-1357,1360,共3页Laboratory Medicine and Clinic

基　　金：广东省科技计划项目(2011B031800207)

摘　　要：目的探讨乳腺癌术后随访中糖链抗原(CA)153、CA125及癌胚抗原(CEA)的价值。方法选取2013年8月至2014年8月该院收治的98例乳腺癌复发转移患者,107例乳腺癌未复发转移患者作为研究对象,分别检测其血清CA153、CA125及CEA,并进行统计学分析。结果复发转移组CA153、CA125及CEA水平均明显高于未复发转移组,差异有统计学意义(P<0.01)。CA153曲线下面积(AUC)大于CA125和CEA,当cut off值为21.79ng/mL时,Youden指数最大,敏感度为80.8%,特异性为91.6%。logistic回归分析表明,CA153对乳腺癌复发转移有较高的预测效能。结论 CA153、CA125及CEA可为临床早期、准确诊断乳腺癌复发转移提供参考依据,且CA153的诊断价值优于CA125及CEA。Objective To explore the value of CA153,CA125 and earcinoembryonic antigen（CEA） detection in follow up of postoperative breast cancer. Methods A total of 98 patients suffering from breast cancer recurrence （recurrence group）and 107 patients without recurrence（non recurrence group） as the subject in this research from August 2013 to August 2014. All of patients were detected CA153,CA125 and CEA,and the data were statistical analyzed. Results The level of CA153 ,CA125 and CEA in the recurrence group was significant higher than the non recurrence group,the difference was statistical significant （P〈0.01）. The area under receiver operating characteris tic curve（AUC） of CA153 was bigger than CA125 and CEA,when the cutoff score was 21.79 ng/mL,the Youden index was the biggest, the sensitivity was 80.8% and the specificity was 91.6 %. According to the logistic regression analysis,the prediction efficiency of CA153 was better than CA125 and CEA. Conclusion The level of CA153 ,CA125 and CEA could provide reference for the early diagnosis of breast cancer recurrence and the diagnostic value of CA153 is better than CA125 and CEA.

关 键 词：乳腺癌 糖链抗原153 糖链抗原125 癌胚抗原 

分 类 号：R735[医药卫生—肿瘤]