帕金森病个体化诊疗的依从性与疾病进展的相关性分析  

Correlation analysis of individualized treatment compliance and disease progression in patients with Parkinson disease

作　　者：赵航[1,2] 葛晗明 梁战华[2] 王琰[2] 

机构地区：[1]大连医科大学附属第一医院神经内科,辽宁大连116011 [2]西安医学院第一附属医院神经内科,陕西西安710000

出　　处：《临床荟萃》2015年第5期499-502,共4页Clinical Focus

基　　金：国家863计划合作项目(2006AA02A408)

摘　　要：目的研究个体化诊疗方案的依从性与疾病进展的相关性。方法入组的所有患者在初次就诊时制定帕金森病(PD)的个体化诊疗方案,并要求患者每隔3个月来医院复诊1次,对该患者的个体化治疗方案进行调整。将患者分为3组(第1组:每隔3个月复诊;第2组:每隔6个月复诊;第3组:每隔12个月复诊),患者在初诊时(OM),6个月复诊时(6M),12个月复诊时(12M)应用Hoehn-Yahr分级,UPDRS量表,Schwab量表对患者进行评分。结果复诊频率不同的3组Hoehn-Yahr分级的比较差异无统计学意义(P>0.05);3组在初诊时的UPDRS量表、Schwab量表的评分与12个月复诊时的评分比较差异有统计学意义(P<0.01)。结论系统规范的个体化诊疗方案可以延缓PD疾病的进展,并改善日常生活活动,延长患者独立生活的时间,从而提高患者的生活质量。Objective To explore the correlation of individualized treatment compliance and disease progression in Parkinson disease（PD）.Methods Individualized treatment strategy was made for the patients in this study in the first visit,each patient should come back to visit every three months and treatment program will be adjusted based on disease situation.All patients were divided into three groups （Group 1：return visit every 3 months;Group 2：return visit every 6 months;Group 3：return visit every 12 months）.Patients will be evaluated in the first visit after 6 months and after 12 months by Hoehn-Yahr scale,UPDRS scale and Schwab scale.Results There were no significant difference in Hoehn-Yahr grade among three groups （P 〉0.05）.There were significant differences in the rating score evaluated by UPDRS scale and Schwab scale between return visit in the first time and return visit after 12 months among three groups （P 〈 0.01 ）.Conclusion The systematical and normative individual treatment could delay the disease progression,prolong the time of independent activity,improve activities of daily life and the life quality of the patients.

关 键 词：帕金森病 个体化医学 病人依从 评价研究 

分 类 号：R742.5[医药卫生—神经病学与精神病学]