重症脑卒中患者肠黏膜屏障功能的变化  

Functional changes of intestinal mucosal barrier in patients with severe stroke

作　　者：王惠凌[1] 姜源涛[2] 张红[3] 宋月平[1] 黎海辉[3] 冉小芳[3] 李震中[4] 张海静 苏彦超 

机构地区：[1]河北大学附属医院神经内科重症监护病房,河北保定071000 [2]河北大学附属医院骨科,河北保定071000 [3]保定市第五医院烧伤科,河北保定071000 [4]河北医科大学第二医院神经内科,河北石家庄050017 [5]涞水县医院神经内科,河北保定074100 [6]易县医院神经内科,河北易县074200

出　　处：《临床荟萃》2015年第5期529-532,共4页Clinical Focus

摘　　要：目的探讨重症脑卒中患者是否存在肠黏膜屏障功能变化。方法选取重症脑卒中患者67例,按发病部位分为4组,即脑干出血组、脑干梗死组、半球出血组、大面积半球梗死组,分别于患病后24小时、72小时、2周、4周采集静脉血,同时选取健康体检者30例作为对照组,抽取外周血,采用双抗体夹心酶联免疫吸附实验(ELISA)法测定血清二胺氧化酶(Diamine oxidase,DAO)、D-乳酸(D-lactic acid,D-LAC)含量。结果与对照组比较,重症脑卒中组D-LAC、DAO均明显升高(均P<0.01)。脑卒中组不同时点比较表明:4组间比较差异均有统计学意义(均P<0.01)。各组从发病24小时至2周均处于高水平,不同时点比较差异无统计学意义(均P>0.05)。结论重症脑卒中患者病后24小时内即可出现黏膜屏障功能损伤,并且损害可持续2周或更长时间。Objective To explore the functional changes of intestinal mucosal barrier in patients with severe stroke.Methods A total of 67 patients with severe stroke were enrolled in this study.Based on affected sites,all cases were divided into brainstem hemorrhage group,brainstem infarction group,hemispheric hemorrhage group and massive hemispheric infarction group.Venous blood was collected at 24 hours,72 hours,2 weeks,4 weeks for serum D-LAC and DAO by ELISA.The same detections were conducted in 30 healthy individuals as comparison.Results Compared with control group,both D-LAC and DAO were significantly elevated in patients with severe stroke （P 0.05）.Conclusion Injury in mucous membrane barrier function occurs in patients with severe stroke in 24 hours after illness onset,and it can last for 2 weeks or longer.

关 键 词：卒中 肠黏膜 脑出血 脑干梗死 

分 类 号：R743[医药卫生—神经病学与精神病学]