改良小梁切除术联合生物羊膜和丝裂霉素C治疗难治性青光眼  

The treatment of refractory glaucoma with modified trabeculectomy combined with biological amniotic membrane transplantation and mitomycin C

作　　者：鲁诚[1] 魏盟[1] 魏承丽[1] 

机构地区：[1]新乡市第一人民医院眼科,河南453003

出　　处：《中华眼外伤职业眼病杂志》2015年第5期365-368,共4页Chinese Journal of Ocular Trauma and Occupational Eye Disease

摘　　要：目的 探讨改良小梁切除术联合应用生物羊膜和丝裂霉素C治疗难治性青光眼的临床效果.方法 将难治性青光眼30例（32眼）随机均分为联合组和对照组.联合组施行改良小梁切除术＋巩膜瓣下丝裂霉素C处理＋生物羊膜移植;对照组施行传统小梁切除术.比较两组术前、术后1周、1个月、6个月、1年的视力、滤过泡和眼压.结果 术后1周两组视力差异无统计学意义;术后6个月及1年,联合组保持功能性滤泡率高于对照组差异有统计学意义;术后1周、6个月及1年联合组眼压均低于对照组;差异均有统计学意义.结论 改良小梁切除术联合应用生物羊膜和丝裂霉素C,可有效治疗难治性青光眼.Objective To evaluate the clinical effect of modified trabeculectomy combined with biological amniotic membrane transplantation and mitomycin C for the treatment of refractory glaucoma.Methods Thirty-two eyes of 30 patients with refractory glaucoma were randomly divided into the combined therapy group and the control group.In combined therapy group,after performing modified trabeculectomy and mitomycin C,biological amniotic membrane was implanted under the sclera flap.In control group,only traditional trabeculectomy was proformed.Visual acuity,filtering bleb and intraocular pressure were compared between two groups at pre-operation and 1 week,1 month,6 months and 1 year after the operation.Results There was no statistically significant difference in visual acuity between two groups at 1 week after the operation.At 6 months and 1 year after the operation,cases with functional filtering bleb in the combined therapy group were more than that in control group.At 1 week,6 months and 1 year after the operation,the intraocular pressure in combined therapy group was lower than that in control group,and the differences were statistically significant.Conclusion Modified trabeculectomy combined with biological amniotic membrane transplantation and mitomycin C is effective for the treatment of refractory glaucoma.

关 键 词：青光眼 难治性 小梁切除术 改良 生物羊膜 丝裂霉素C 

分 类 号：R779.6[医药卫生—眼科]