急性脊髓炎患者血清及脑脊液白蛋白 免疫球蛋白及β-AP Tau蛋白的变化  

Research on the change of serum and CSF albumin,immunoglobulin and beta AP and Tau protein in patients with acute myelitis

作　　者：叶玉兰[1] 叶雪梅[2] 

机构地区：[1]成都市第一人民医院神经内科,四川成都610041 [2]眉山市人民医院重症医学科,四川眉山620010

出　　处：《西部医学》2015年第6期891-893,共3页Medical Journal of West China

摘　　要：目的 研究急性脊髓炎患者血清及脑脊液白蛋白、免疫球蛋白及β-AP、Tau的变化.方法 筛选神经内科2013年5月～2014年3月行脑脊液检查的患者67例,按是否为急性脊髓炎将患者分为疾病组32例和对照组35例,分别行血清及脑脊液微量清蛋白、免疫球蛋白及β-AP、Tau蛋白检测,并进行对比分析.结果 与对照组比较,疾病组患者SAlb无明显差异（P＞0.05）;CAlb和QAlb明显升高,差异有统计学意义（均P＜0.05）;SIgG、CIgG、IgG指数和IgG-syn均显著升高,差异均有统计学意义（均P＜0.05）;CSF-OCB阳性患者9例,阳性率为28.1％,两组间差异有统计学意义（P＜0.05）;血清β-AP、脑脊液β-AP、血清Tau蛋白和脑脊液Tau蛋白均无明显变化,差异无统计学意义（均P＞0.05）.结论 急性脊髓炎患者早期就已经出现血脑屏障损害,SAlb、CAlb及QAlb能作为判断血脑屏障损害的指标,并用于神经系统炎性疾病和非炎性疾病的鉴别诊断;急性脊髓炎患者存在免疫球蛋白指标的异常,提示其疾病的发生和自身免疫相关;急性脊髓炎患者早期β-AP及Tau蛋白未出现明显异常,提示早期急性脊髓炎尚未出现神经功能的损害,对判断疾病的进展和预后具有重要的临床价值.Objective To study the change of the Serum and CSF albumin, immunoglobulin and beta AP and Tau protein in patients with acute myelitis. Methods 67 patients with eerebrospinat fluid examination were divided into disease group and the control group according to whether suffered from acute myelitis. The albumin,immunoglobulin and β-AP, Tau protein in serum and cerebrospinat fluid were examined and compared. Results Compared with control group, the SAlb of the disease group had no significant differences （P〈0.05）. The CAlb and QAlb increased significant- ly （P〈0.05）. SIgG, ClgG, IgG and IgG-syn indexes were significantly elevated （P〈0. 05）. There were 9 patients in the disease group with CSF - OBC positive and the positive rate was 28.1%. The difference between the two groups was sta- tistically significant（P〈0.05）. There was no obvious change of β-AP and Tau protein in both serum and cerebrospinal fluid. The difference is no statistically significant （P 〉 0.05）. Conclusion There is blood-brain barrier damage in patients with acute myelitis at the early stage, SALB, CALB and QALB can be used as judgment for the blood-brain bar- rier damage and also can be used to identify inflammatory diseases of nervous system and the differential diagnosis of inflammatory disease;there are abnormalities of immunoglobulin index in patients with acute myelitis which prompt their disease related with autoimmune. There are no obvious changes of β-AP and Tau protein in patients with acute myelitis at the early stage which prompt that there is no damage of nerve function.

关 键 词：急性脊髓炎 血清 脑脊液 免疫球蛋白 Β-淀粉样蛋白 TAU蛋白 

分 类 号：R744.3[医药卫生—神经病学与精神病学]