响应面优化番茄红素微胶囊片的处方工艺  

The process technique of lycopene microcapsules tablets with the method of response surface optimization

作　　者：向琴琴[1] 白羽嘉[1] 曹艳[1] 段继华 辛鹏飞[1] 冯作山[1] 

机构地区：[1]新疆农业大学食品科学与药学学院,乌鲁木齐830052 [2]乌鲁木齐创新源生物科技有限公司,乌鲁木齐830000

出　　处：《食品科技》2015年第5期99-104,共6页Food Science and Technology

基　　金：科技部科技型中小企业技术创新基金项目(10C26226505484)

摘　　要：目的:研究番茄红素微胶囊片的最优处方工艺。方法:在单因素基础上,用响应面分析法优化与制备工艺相关的辅料,包括微晶纤维素、羟丙基甲基纤维素、7.5%聚乙烯吡咯烷酮(PVP)水溶液、硬脂酸镁最佳添加量因素。结果:片剂辅料最佳添加量为微晶纤维素33.82g、羟丙基甲基纤维素22.67 g、7.5%PVP水溶液1.01 m L、硬脂酸镁3.00 g。结论:理论值与模型预测值相吻合。响应面可应用于番茄红素微胶囊片制备工艺的优化分析。Objective： To optimize the process technique of the lycopene microcapsules tablets. Method： Based on the single factor, to optimize the materials associated with the method of response surface, including microcrystalline cellulose, hydroxypropyl methyl cellulose, 7.5% polyvinylpyrrolidone（PVP） solution., the optimum addictive amount of magnesium stearate. Results： The optimum additive amount of microcrystalline cellulose, hydroxypropylmethylcellulose, 7.5% PVP aqueous solution, magnesium stearate should be 33.83 g, 22.67 g, 1.01 m L, 3.00 g. Conclusion： The theoretical value matches with that of the model prediction. The method of response surface can be used for the optimization and analysis of the process of the lycopene microcapsules tablets.

关 键 词：番茄红素微胶囊片 响应面优化法 制备工艺 

分 类 号：TS218[轻工技术与工程—粮食、油脂及植物蛋白工程]