莪术油注射液在胃癌患者围手术期应用的临床意义  

Clinical Significance of Zcdoary Turmeric Oil Injection in Application for Perioperative Patients with Gastric Cancer

作　　者：王冬[1] 李勇[1] 赵群[1] 范立侨[1] 张志栋[1] 刘羽[1] 崔平[2] 

机构地区：[1]河北医科大学第四医院,河北石家庄050011 [2]河北省人民医院,河北石家庄050051

出　　处：《肿瘤学杂志》2015年第5期378-381,共4页Journal of Chinese Oncology

基　　金：河北省中医药管理局科研计划项目(2014145D)

摘　　要：[目的]探讨胃癌患者围手术期应用莪术油注射液的作用及意义。[方法]将80例确诊为胃癌并行肿瘤切除手术的患者分为研究组和对照组,每组40例。研究组术前3天开始给予莪术油葡萄糖注射液0.2g 1次/d,至手术后第6d,共给药10d;对照组给予等量葡萄糖注射液。流式细胞术(FCM)检测2组手术后肿瘤细胞周期和凋亡情况;术前及术后第7d检测两组患者血清炎性因子白细胞介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)的水平。[结果]两组患者的各项临床数据均无明显差异(P>0.05),研究组无药物相关性不良反应。研究组胃癌细胞G0/G1期比率明显高于对照组,S期细胞的比率低于对照组;研究组肿瘤细胞凋亡率明显高于对照组(均P<0.05)。两组患者术前血清IL-2、TNF-α、CRP的水平无明显差异(P>0.05);术后第7d研究组患者血清IL-2、TNF-α、CRP水平均明显低于对照组(P<0.05)。[结论]莪术油注射液可抑制胃癌细胞生长、促进凋亡,并可减轻手术导致的炎症反应。[Purposel To investigate the clinical significance of Zcdoary Turmeric oil injection in application for perioperative patients with gastric cancer. [Methods] Eighty cases with gastric cancer undergoing gastrectomy were divided into 2 groups （40 cases in each group）. The study group accepted Zcdoary Turmeric oil and glucose injection（0.2g once a day） for 10 days（from 3d preoperation to 6d postoperation）, and control group accepted equal glucose injection. Cell cycle, apoptotic rate were tested with flow cytometry （FCM）. And serum IL-2,TNF-a,C reactive protein （CRP） levels were tested preoperatively and the 7th day postoperation in both groups. [Resultsl There was no significant difference between 2 groups about clinical data （P〉0.05）, and no obvious toxicity was observed in study group. Ratio of cells in Go/G1 phase of study group was higher than that of control group, whereas ratio of cells in S phase of study group was lower than that of con- trol group;apoptotic rate of tumor cells in study group was higher than that in control group （P〈 0.05）. There was no obvious difference in levels of IL-2,TNF-a,CRP between 2 groups preopera- tively （P〉0.05）,while levels of IL-2,TNF-a,CRP in study group were lower than those in control group in the 7th day postoperation（all with P〈0.05）. [Conclusion] Zcdoary Turmeric oil could in- hibit growth and promote apoptosis of gastric cancer cells, also it could relieve postoperative in- flammatory reaction.

关 键 词：胃肿瘤 莪术油注射液 围手术期 流式细胞术 炎症反应 

分 类 号：R735.2[医药卫生—肿瘤] R273[医药卫生—临床医学]