Ki-67、P53和CyclinD1在小肠腺癌中的作用  

The significance of Ki-67,P53 and CyclinD1 in small intestine adenocarcinoma

作　　者：黄缘[1] 王素琴[1] 邹文雄[1] 李军[1] 王建强[1] 熊艳艳[1] 

机构地区：[1]南昌大学第二附属医院消化内科,南昌330006

出　　处：《新医学》2015年第5期303-307,共5页Journal of New Medicine

基　　金：江西省卫生厅科技计划(20063108)

摘　　要：目的探讨Ki-67、P53及CyclinD1在小肠腺癌中的表达情况及意义。方法采用SP法检测84例小肠腺癌标本中Ki-67、P53和CyclinD1在不同分化程度、年龄及性别的表达情况,与10例正常小肠组织进行对照,并进行统计学分析。结果 Ki-67、P53和CyclinD1在正常组织中未表达,而在小肠腺癌的表达随肿瘤分化程度的降低而升高。高分化、中分化及低分化各组间比较都有明显差异(P<0.05)。Ki-67、P53和CyclinD1在小肠腺癌的表达以中等强度为主。Ki-67、P53和CyclinD1表达在不同性别、年龄组之间比较差异无统计学意义(P>0.05)。结论 Ki-67、P53和CyclinD1在小肠腺癌的恶性程度判断方面有一定的指导意义。Objective To investigate the expression levels and clinical significance of Ki-67,P53 and CyclinD1 in patients with small intestine adenocarcinoma.Methods The expression levels of Ki-67,P53 and CyclinD1 in tumor tissue from 84 small intestine adenocarcinoma patients with different degree of tumor dif-ferentiation,ages and gender were examined with SP,and normal intestinal tissues from 10 healthy individuals were used as control.Results Ki-67,P53 and CyclinD1 were not expressed in normal small intestinal tis-sues,whereas the expression levels of Ki-67,P53 and CyclinD1 in small intestine adenocarcinoma samples were significantly elevated along with the declining degree of tumor differentiation with statistical significance a-mong the high-,moderate-and low-differentiation groups（all P 〈0.05）.Ki-67,P53 and CyclinD1 were ex-pressed at a moderate intensity in a majority of small intestine adenocarcinoma samples.The expression of Ki-67, P53 and CyclinD1 did not significantly differ in terms of gender and age（both P 〉0.05）.Conclusion Ki-67, P53 and CyclinD1 may provide guidance for evaluating the malignancy of small intestine adenocarcinoma.

关 键 词：KI-67 P53 CYCLIND1 小肠腺癌 免疫组织化学 

分 类 号：R735.32[医药卫生—肿瘤]