促甲状腺激素降低与脑卒中后抑郁的相关性研究  

Study on correlation between TSH decrease and post-stroke depression

作　　者：陈劲松[1] 林贵喜 姚键[1] 

机构地区：[1]广东医学院附属惠东医院神经内科,广东惠东516300

出　　处：《重庆医学》2015年第15期2040-2041,2044,共3页Chongqing medicine

基　　金：广东省医学科研基金青年项目(B2013410)

摘　　要：目的探讨促甲状腺激素(TSH)降低与脑卒中后抑郁的相关性。方法收集2012年10月至2014年7月该院住院治疗的急性脑梗死患者101例,根据TSH是否小于0.27uIU/mL分成TSH降低组和TSH正常组。入院时两组患者分别进行神经功能缺损(NIHSS)评分,出院后随访3个月分别进行汉密尔顿抑郁量表(HAMD)评分和改良的Rankin量表(mRS)评分。结果 TSH降低组3个月时的HAMD评分(16.04±3.34 vs.14.03±3.47,P=0.000)、mRS均明显高于TSH正常组(3.2±1.1vs.2.1±1.5,P=0.000)。TSH降低组预后差的比率(89.3%)高于TSH正常组(38.4%)。结论 TSH浓度降低与脑卒中后抑郁可能存在相关性,TSH浓度低的急性脑梗死患者预后较差。Objective To study the correlation between TSH decrease and post‐stroke depression .Methods 101 patients with acute brain infarction in our hospital from October 2012 to July 2014 were collected as the study subjects and divided into the TSH decrease group and the TSH normal group according to whether serum TSH levels less than 0 .27 uIU/mL .The two groups were evaluated on admission by the National Institute of Health Stroke Scale （NIHSS） ,at 3 months after discharge by modifies Rankin′s Scale（mRS）and the Hamilton Depression Scale（HAMD）respectively .Results The HAMD scores at 3 months in the TSH decrease group were significantly higher than those in the TSH normal group （16 .04 ± 3 .34 vs .14 .03 ± 3 .47 ,P=0 .000）and the mRS scores NIHSS score were significantly higher than those in the TSH normal （3 .2 ± 1 .1 vs .2 .1 ± 1 .5 ,P〈0 .05）） .The ra‐tio of poor prognosis in the TSH decrease group was higher than that in the TSH normal group （89 .3% vs .38 .4% ,P〈0 .05） ,in‐dicating that the prognosis in the TSH decrease group was poor .Conclusion The correlation could exist between the decrease of TSH level with post‐stroke depression .In acute brain infarction ,the patient with low TSH level could have the poor prognosis .

关 键 词：脑梗死 促甲状腺激素 卒中后抑郁 预后 

分 类 号：R743.3[医药卫生—神经病学与精神病学]