天津地区汉族人群rs798766单核苷酸多态性与膀胱尿路上皮癌发病风险相关性  

Association between polymorphism of rs798766 and urothelial bladder cancer risk from Han population of Tianjin

作　　者：乔志辉 王仁杰 谢万青 孙岩[2] 吴长利[1,2] 胡海龙[1,2] 

机构地区：[1]天津医科大学第二医院泌尿外科,天津300211 [2]天津市泌尿外科研究所,天津300211 [3]太原钢铁(集团)有限公司总医院泌尿外科,太原030003

出　　处：《天津医科大学学报》2015年第3期208-211,共4页Journal of Tianjin Medical University

基　　金：国家自然科学基金资助项目(30700834);天津市自然科学基金资助项目(12ZCDZSY16600);天津市应用基础与前沿技术研究计划项目(14JCYBJC26300)

摘　　要：目的：探讨rs798766单核苷酸多态性与天津地区汉族人群膀胱尿路上皮癌发病风险的关系。方法：采用等位基因特异性PCR技术对363例膀胱尿路上皮癌患者（试验组）和384例对照人群（对照组）的基因型进行分型。结果：试验组rs798766 T等位基因频率为15.3%,C等位基因频率为84.7%;对照组T等位基因频率为10.5%,C等位基因频率为89.5%,两组T等位基因频率分布存在明显的统计学差异（P=0.006;校正OR=1.53;95%CI为1.13~2.08）。与基因型C/C相比,rs798766（C/T＋T/T）基因型明显增加膀胱尿路上皮癌的发病风险（P=0.006;校正OR=1.61;95%CI为1.14~2.25）;病理分层分析显示,rs798766单核苷酸多态性与膀胱癌病理分期、分级无相关性。结论：Rs798766 T等位基因明显增加天津地区汉族人群膀胱尿路上皮癌发病风险,可能是预测天津地区汉族人群膀胱癌发病风险的良好基因标记。Objective：To assess the association between single nucleotide polymorphism（SNP） of rs798766 with urothelial bladder cancer（UBC）risk in a case-control study from Han population of Tianjin. Methods： Genotypes were analyzed using a PCR amplification of specific alleles（PASA） method in 364 patients with UBC and 384 matched healthy controls. Results： The frequency of allele T in patients group was 15.3%, and allele C 84.7%. The frequency of allele T in controls group was 10.5%, and allele C 89.5%. There was a significant difference between the two groups（P=0.006, adjusted OR=1.53;95%CI=1.13-2.08）. Compared with the C/C genotype, rs798766（C/T＋T/T）genotypes could significantly increase the risk of UBC（P=0.006, adjusted OR=1.61;95%CI=1.14-2.25）. Stratification analysis of pathology showed that the association of rs798766 with tumor grade/stage for bladder cancer was not statistically significant. Conclusion： The results indicate that rs798766 T allele could significantly increase the risk of UBC, and may be used as a genetic marker to evaluate the susceptibility for UBC in Han population of Tianjin.

关 键 词：膀胱尿路上皮癌 单核苷酸多态性 全基因组关联研究 遗传易感性 天津 

分 类 号：R737.14[医药卫生—肿瘤]