TMD患者电刺激后唾液皮质醇变化及与疼痛灾难化认知的关系  

Salivary cortisol response to electrical stimulation in TMD cases and its relation with pain catastrophizing

作　　者：李雪[1] 张娟[1] 王雨生[2] 

机构地区：[1]天津医科大学口腔医院修复科,300070 [2]天津医科大学口腔医院解剖生理教研室

出　　处：《实用口腔医学杂志》2015年第3期374-377,共4页Journal of Practical Stomatology

摘　　要：目的:研究颞下颌关节紊乱病(TMD)患者电刺激后唾液皮质醇变化及与疼痛灾难化认知的相关性。方法:选11名TMD患者与11名正常人进行电刺激实验,分别于刺激前、刺激50、100 s后收集唾液,用ELISA酶联免疫分析皮质醇浓度;受试者在刺激前填写疼痛灾难化认知量表(PCS),统计学分析数据。结果:TMD患者皮质醇浓度高于对照组(P<0.05),随着电刺激时间延长,皮质醇浓度呈下降趋势;时间因素与处理分组无交互作用。PCS总分及3项指标(反复思虑、夸大、无助)均与刺激前皮质醇浓度呈正相关。结论:不可预知性应激使唾液皮质醇浓度升高,与疼痛灾难化认知有关。Objective：To analyse the salivary cortisol changes in patients with temporomandibular disorders（TMD）after electrical stimulation,and the relationship between cortisol and pain catastrophizing.Methods：1 1 TMD and 1 1 healthy subjects were evoked by electrical stimulation.The saliva samples were collested before test,50 s and 1 00 s of stimulation after test seperately.Salivary cortisol was analysed by ELISA kit.The pain catastrophizing scale（PCS）was answered by all the subjects before stimulation.Data were statis-tically analysed.Results：The salivary cortisol concentration in TMD patients was higher than that in the controls（P〈0.05）.After stimulation,it showed a downward trend.No interaction between time and groups.The total scores of PCS including three indexes（ru-mination,magnification,helpless）were positively correlated with salivary cortisol concentration.Conclusion：The unpredictable stress causes high level of cortisol.which is related to pain catastrophizing.

关 键 词：颞下颌关节紊乱病(TMD) 电刺激 不可预知性应激 唾液皮质醇 疼痛灾难化认知(PCS) 

分 类 号：R782.6[医药卫生—口腔医学]