A型肉毒素治疗三叉神经痛的系统评价  

Evaluation of the efficacy of botulinum toxin type A in the treatment of trigeminal neuralgia

作　　者：梁志红 黄稔欢[2] 史宗道[2] 

机构地区：[1]上海虹口区牙病防治所,200081 [2]四川大学华西口腔医学院

出　　处：《实用口腔医学杂志》2015年第3期401-406,共6页Journal of Practical Stomatology

摘　　要：目的:评价A型肉毒素(BTX-A)注射治疗三叉神经痛的疗效。方法:对A型肉毒素注射治疗三叉神经痛的随机对照试验(RCT)进行系统评价。结果:纳入4个A型肉毒素注射治疗三叉神经痛的随机对照试验,共纳入203人。各研究间异质性较大,对结果分别进行描述。3项试验报道试验组疗效优于对照组,1项试验报道试验组与对照组无显著差异。4项试验均报道副作用少见,且为轻到中度。结论:A型肉毒素注射治疗三叉神经痛有一定疗效,无明显副作用,但尚需更多高质量的研究验证。Objective：To review the clinical efficacy of botulinum toxin type A（BTX-A）in the treatment of trigeminal neuralgia （TN）.Methods：The main bibliographic databases were searched from English and Chinese literatures on the topic and the refer-ences of the identified articles were also searched for additional studies.2 reviewers assessed the quality of the included studies and extracted data duplicate.Results：3 Chinese and 1 English reports with 203 participants were included.However,substantial hetero-geneity（I2 =77%）precluded meta-analysis and the results were individually described.3 trials reported that BTX-A was more effec-tive than the control and 1 showed no difference between groups.Adverse effects of BTX-A were reported in 4 reports and were mild to moderate.Conclusion：BTX-A is effective in treating TN with few adverse effects.However,the evidence is weak because of a few studies included and most of them with low methodological quality.Further studies with high quality are needed to testify the evidence.

关 键 词：三叉神经痛 肉毒素A(BTX-A) 随机对照试验 

分 类 号：R745.11[医药卫生—神经病学与精神病学]