槲皮素铋的合成及其生物活性研究  

Synthesis,Characterization and Biological Activity of Quercetin-Bismuth Complexes

作　　者：翟广玉[1,2] 渠文涛[2] 马海英[1] 韩冰[1] 樊卫华[1] 

机构地区：[1]郑州大学护理学院 [2]郑州大学药学院,郑州450052

出　　处：《天然产物研究与开发》2015年第5期896-899,904,共5页Natural Product Research and Development

基　　金：郑州大学大学生创新创业训练计划(2014xjxm312)

摘　　要：本文介绍了槲皮素铋的合成方法,并通过紫外光谱、红外光谱、核磁氢谱、同步热分析进行了表征。氢谱显示铋离子在3'-OH位置与槲皮素配位,同步热分析确证了这个结果。通过DPPH法测定了槲皮素铋清除自由基的能力,结果显示,槲皮素铋清除DPPH自由基的能力弱于槲皮素。This paper introduced the synthesis method of quercetin-bismuth complexes. The composition of the synthesized complexes was characterized by UV-visible,IR,^1H NMR spectroscopies and synchronous thermal analysis techniques.^1H-NMR spectrum displayed quercetin chelated with bismuth ions at 3＇-OH position. This result was confirmed by simultaneous thermal analysis. The antioxidants activity of the complexes was evaluated using 1,1-diphenyl-2-picrylhydrazyl（ DPPH）. It was shown that DPPH radical scavenging activity of free quercetin was decreased after chelation of bismuth cation.

关 键 词：槲皮素 槲皮素铋 合成 结构表征 自由基 

分 类 号：R914.5[医药卫生—药物化学]