淀粉基聚合物胶束用作药物载体  

Polymeric Micelles Based on Starch as Drug Carriers

作　　者：杨金龙[1] 高春梅[1] 吕少瑜[1] 陈名家 柳明珠[1] 

机构地区：[1]兰州大学化学化工学院功能有机分子化学国家重点实验室,兰州730000

出　　处：《高分子学报》2015年第6期617-623,共7页Acta Polymerica Sinica

基　　金：国家自然科学基金(基金号51273086);教育部高等学校博士点专项科研基金(基金号20130211110017)资助项目

摘　　要：两亲性聚合物能通过亲疏水作用自组装为核-壳结构,而这独特的优势已使其成为在肿瘤靶向药物缓释方面具有很好发展前景的药物载体.淀粉原材料来源丰富,价格低廉,同时具有良好的生物相容性和生物可降解性,故基于淀粉的两亲性聚合物胶束正引起越来越多研究者极大的关注.作为药物载体,淀粉基聚合物胶束不仅可以提高药物的水溶性、延长药物在体内的循环时间、降低副作用和通过增强渗透与滞留(EPR)效应提高药物在靶向部位的优先累积,还可以在淀粉骨架上引入一些刺激响应型的官能团实现胶束快速靶向释药的功能.因此,淀粉基聚合物胶束在用作药物载体方面有着广阔的发展潜力.本文结合本课题组目前的研究工作和近几年的相关报道对淀粉基聚合物胶束作为药物载体的最新研究进展做简要综述.Amphiphilic polymers have shown great potential as the promising drug carriers for tumor-targeting drug delivery applications due to their own unique advantage that they can self-assemble into micelles with core-shell structures by the hydrophilic-hydrophobic interaction in aqueous solution. Recently,amphiphilic polymeric micelles based on starch are receiving more and more attention because of their abundant resource and low price of starch,and the good biocompatibility and biodegradability. As drug carriers,polymeric micelles based on starch can improve the solubility of hydrophobic drug,extend drug circulation time in vivo,reduce systemic side effects and increase the preferential acculation at the targeted sites by the enhanced permeability and retention（ EPR） effect. In addition,compare with the traditional micellar systems,some groups with stimuli-responsive functions can be easily introduced to starch backbone to prepare smart polymeric micelles realizing rapid and targeted release drug. Therefore,due to these features above,polymeric micelles based on starch as drug carriers have broad development potential. The review highlights the latest progress in polymeric micelles based on starch as novel drug carriers.

关 键 词：淀粉 聚合物胶束 药物载体 

分 类 号：O636.12[理学—高分子化学] TQ460.1[理学—化学]