S100B蛋白在神经系统疾病中的临床意义及进展  

The Clinical Significance and Research Progress of the S100B Protein in Nervous System Disease

作　　者：吴珊珊[1] 范宇威 高静[1] 穆卫卫 张黎明[1] 

机构地区：[1]哈尔滨医科大学附属第一临床医院神经内科,黑龙江哈尔滨150001

出　　处：《现代生物医学进展》2015年第16期3197-3200,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81271288)

摘　　要：S100B蛋白是主要由神经胶质细胞分泌的一种钙结合蛋白,在生理浓度下,S100B蛋白具有旁分泌或自分泌神经营养作用,高浓度时则具有神经毒害作用。脑脊液、血液、尿液、唾液、羊水等体液中S100B蛋白水平的升高被认为是多种疾病的生物学指标,如急性脑损伤、围产期脑损伤、脑肿瘤、神经系统炎症性或退行性疾病,精神疾病等。S100B蛋白不仅仅是一种生物学指标,也可作为疾病治疗的靶向目标。目前存在的主要问题是,S100B蛋白主要由受损细胞渗漏,还是病理生理条件下分泌的S100B蛋白造成了细胞损伤。本文就S100B蛋白在神经科疾病中的诊断、治疗及新进展做一综述,并提出进一步研究的设想。S100B protein is a calcium-binding protein concentrated in glial cells. S100 B protein has paracrine/autocrine trophic effects at physiological concentrations, but toxic effects at higher concentrations. Elevated S100 B protein levels in CSF, blood, urine,saliva, and amniotic fluid are regarded as a biomarker of pathological conditions, including acute brain injury, perinatal brain distress,brain tumors, neuroinflammatory or neurodegenerative disorders, and psychiatric disorders. The protein is not only a biomarker but also a potential therapeutic target. The key question remains as to whether S100 B protein is merely leaked from injured cells or is released in physiological and pathological conditions, participating in the events leading to cell injury. This review focuses on the function of S100 B protein in the diagnosis, therapy and research progress of nervous system disease and assumed new directions for further research.

关 键 词：S100B蛋白 生物学指标 炎症反应 神经系统疾病 

分 类 号：R742[医药卫生—神经病学与精神病学]