阿仑膦酸钠联合化疗对多发性骨髓瘤患者骨代谢的影响  

The Effect of Alendronate in Combination with Chemotherapy on Bone Metabolism in Patients with Multiple Myeloma

作　　者：饶进[1] 殷莉[1] 林志美[1] 熊萍[1] 苟晓琴[1] 

机构地区：[1]成都大学附属医院血液科,四川成都610081

出　　处：《现代生物医学进展》2015年第17期3253-3255,共3页Progress in Modern Biomedicine

摘　　要：目的:研究阿仑膦酸钠联合化疗对多发性骨髓瘤患者骨代谢的影响。方法:选取2011年4月到2014年4月我院收治的多发性骨髓瘤患者130例,按照随机数字表法将患者分为研究组和对照组,每组65例,对照组给予化疗,研究组在对照组的基础上给予阿仑膦酸钠,比较两组骨特异性碱性磷酸酶(BAP)、骨钙素(OC)、I型前胶原氨基肽(PINP)、血钙(Ca)、血磷(P)、β胶原特殊序列(β-CTx)以及碱性磷酸酶(ALP)。结果:治疗后研究组OC、PINP和BAP均显著高于治疗前和对照组,比较差异均有统计学意义(P<0.05);治疗后研究组β-CTx显著低于治疗前和对照组,比较差异均有统计学意义(P<0.05)。结论:阿仑膦酸钠联合化疗治疗多发性骨髓瘤患者能显著改善其的骨代谢,值得临床推广。Objective： To study the effect of alendronate in combination with chemotherapy on bone metabolism in patients with multiple myeloma. Methods： 130 cases with multiple myelomawho treated in our hospital from April 2011 to April 2014 were selected,they were divided into the study group and the control group according to a random number table, 65 cases in each group, the patients of the control group were treated with chemotherapy, the patients of the study group were given alendronate on the basis of the control group, bone-specific alkaline phosphatase（BAP）, osteocalcin（OC）, I procollagen amino-peptide（PINP）, calcium, phosphorus, βcollagen special sequences（β-CTx） and alkaline phosphatase of two groups were compared. Results： After treatment, the OC, PINP and BAP of the study group were significantly higher than before treatment andthe control group, the difference was statistically significant（P〈0.05）; The β-CTx of the study group were significantly lower than before treatment and the control group, the difference was statistically significant（P〈0.05）. Conclusion： Alendronate combination with chemotherapy in treatment of multiple myeloma can significantly improve bone metabolism. It is worthy of clinical promotion.

关 键 词：阿仑膦酸钠 化疗 多发性骨髓瘤 疗效 

分 类 号：R733.3[医药卫生—肿瘤]