中药联合化疗对ALL患者CD4、CD25细胞调节及sE-cad的影响  

Effect of Traditional Chinese Medicine Combined with Chemotherapy for Patients with ALL CD4, the Regulation of CD25 Cell and s E-cad

作　　者：方阅[1] 张渊[1] 方敏[1] 刘皋林[1] 白利民[2] 

机构地区：[1]上海交通大学附属第一人民医院,上海200080 [2]南京中医药大学临床学院,江苏南京210046

出　　处：《现代生物医学进展》2015年第18期3466-3469,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(H0136)

摘　　要：目的:研究中药联合化疗方案对急性淋巴细胞白血病(Acute lymphocytic leukemia,ALL)患者CD4+、CD25+细胞调节的影响、血清s E-cad的影响以及临床意义。方法:选取我院血液科收治的急性淋巴细胞白血病患者60例,随机分为两组,其中对照组30例给予常规化疗方案治疗,中药组30例在常规化疗方案的基础上加用中药辅助治疗。对比治疗前后患者血常规、CD4+、CD25+细胞及血清s E-cad的改变。结果:1治疗后两组患者CD4+、CD25+T细胞较治疗前均显著下降,差异有统计学意义(P<0.05),与对照组相比,中药组CD4+、CD25+T细胞下降明显,差异有统计学意义(P<0.05);2治疗后两组患者血清s E-cad均改善,且中药组(55.58±10.47)较对照组(67.27±11.32)明显下降,差异有统计学意义(P<0.05);3两组有效率比较重,中药组总有效率(86.67%)明显优于对照组(66.67%),差异有统计学意义(P<0.05)。结论:中药联合化疗治疗急性淋巴细胞白血病CD4+、CD25+T细胞调节及血清s E-cad的改变明显,对临床具有指导意义。Objective： To study traditional Chinese medicine combined with chemotherapy for acute lymphoblastic leukemia（Acute lymphocytic leukemia, ALL） in patients with CD4^＋CD25^＋cell regulation effect, serum s E-cad and the effect of clinical significance. Methods： 60 patients with acute lymphoblastic leukemia in our hospital chosen from the Department of Hematology were randomly divided into two groups; 30 patients in control group received conventional chemotherapy treatment, 30 cases of the Chinese medicine group were treated by traditional Chinese medicine auxiliary based on conventional chemotherapy. Change the blood routine test, CD4^＋CD25^＋cells and serum s E-cad before and after treatment were compared. Results： After treatment, patients in the two groups with CD4^＋CD25^＋T cells were significantly lower than that before treatment, and the difference was statistically significant（P〈 0.05）;compared with the control group, CD4^＋CD25^＋T cells, the Chinese medicine group decreased significantly, and the difference was statistically significant（P〈 0.05）; after the treatment, serum s E-cad of the two groups of patients were both improved, and decreased significantly in the traditional Chinese medicine group（55.58 ＋ 10.47） than in the control group（67.27 ＋ 11.32）, and the difference was statistically significant（P〈 0.05）; the two group＇s efficiency is relatively heavy, total effective rate of the traditional Chinese medicine group（86.67%） was significantly better than that of the control group（66.67%）, and the difference was statistically significant（P〈 0.05）.Conclusion： Traditional Chinese medicine combined with chemotherapy in the treatment of acute lymphoblastic leukemia CD4＋and CD25＋T cells modulate and serum s E-cad change significantly, has the guidance significance for clinical.

关 键 词：中药 血清s E-CAD CD4^+ CD25^+ 

分 类 号：R733.7[医药卫生—肿瘤]