应用组织芯片技术研究Cullin1在胶质瘤组织中的表达及意义  

Detection of Cullinl expression in gliomas by tissue microarray and its clinical significance

作　　者：朱一硕 张芸[1] 许宁[1] 陈洪福[1] 张慧[1] 梅鹏金[1] 范月超[1] 

机构地区：[1]徐州医学院附属医院神经外科,江苏徐州221002

出　　处：《徐州医学院学报》2015年第4期258-260,共3页Acta Academiae Medicinae Xuzhou

基　　金：江苏省卫生厅科研基金（H201019）

摘　　要：目的探讨胶质瘤组织中Cullin1的表达及其与临床病理资料之间的关系。方法采用免疫组化法检测胶质瘤组织芯片（正常脑组织8例、癌旁组织8例、胶质瘤组织191例）中Cullin1的表达量及其与临床病理资料之间的关系。结果Cullin1在胶质瘤中的表达量明显高于正常脑组织和癌旁组织（P〈0．05），但是在Cullin1表达量和相应临床病理资料之间未发现有任何联系。结论Cullin1在胶质瘤中的表达量明显升高，促进了肿瘤的发生和发展。Objective To measure the amounts of Cullinl （ Cul1 ） in glioma tissues and its relationship with pathological data. Methods In the current study, 8 normal brain tissues and 8 adjacent normal brain tissues and 191 glioma tissues were taken to examine their amounts of Cull by tissue microarray and immunohistoehemistry and its relationship with pathological data. Results Our results showed that glioma tissues presented remarkably increased quantities of Cull than normal and adjacent normal brain tissues （P 〈 0.05 ）. However, no relationship was found between the expression of Cull and pathological data. Conclusion The remarkable rise of Cull expression in human glioma tissues is determined, which may facilitate tumor development and progression.

关 键 词：Cullin1 胶质瘤 组织芯片 免疫组化 

分 类 号：R73[医药卫生—肿瘤]