多西他赛/顺铂联合放射疗法同步治疗局部晚期鼻咽癌的疗效比较  

Comparison of Cisplatinum/Paclitaxe concurrent radiotherapy for advanced nasopharyngeal carcinoma

作　　者：宣小山 田平[1] 谢鸿寿[1] 

机构地区：[1]淮南东方医院集团肿瘤医院放疗五病区,安徽省淮南232033

出　　处：《中国基层医药》2015年第9期1394-1397,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 探讨多西他赛/顺铂联合放疗在局部晚期鼻咽癌治疗中的疗效及不良反应.方法 选取首次治疗的87例局部晚期鼻咽癌患者,随机分为多西他赛组（A组,n=43）与顺铂组（B组,n=44）.化疗方法：A组每周用药1次,每次按30 mg/m2剂量用药,共用6次;B组每3周用药1次,每次按总剂量80～100 mg/m2分3d静脉滴注,共用2次.放疗方法：所有患者均使用头颈肩膜固定,采用调强放射治疗,处方剂量为PGTV、PGTVnd 6 996 cGy/33次,PTV1 6 006 cGy/33次,PTV2 5 096 cGy/28次.结果 放疗结束1个月后A、B两组鼻咽部及颈部病灶治疗的有效率分别为88.4％和86.4％（χ2=0.079,P=0.778）、88.4％和88.6％（χ2=0.000,P=1.000）,差异无统计学意义;但B组口腔黏膜反应（χ2=4.295,P=0.038）及胃肠道反应（χ2=4.482,P=0.028）发生率明显高于A组.结论 晚期鼻咽癌根治性放疗联合多西他赛的治疗疗效与联合顺铂相似,且毒副反应较低,患者耐受性可,近期疗效满意.Objective To observe the acute side effects and recent therapeutical effect of cisplatinum/paclitaxe concurrent radiotherapy for patients with advanced nasopharyngeal carcinoma.Methods 87 patients with advanced nasopharygeal carcinoma were enrolled.According to the treatment,87 patients were divided into paclitaxe group （groupA,n =43） and cisplatinum group （group B,n =44）.The two groups were treated with 6MV-X ray for radiotherapy.The prescription dose of radiation therapy was PGTV,PGTVnd 6 996 cGy/33F,PTV1 6 006 cGy/33F,PTV2 5 096 cGy/28F.The two groups began concurrent chemotherapy in radiotherapy,specific method：group A paclitaxe 30mg/m2,1 time a week,until the end of radiotherapy,group B cisplatinum 80 ～100 mg/m2,every 21 days.Results The recent therapeutical effect of nasopharyngeal lesions and lymph nodes of neck for group A and group B were 88.4% and 86.4% （χ2 =0.079,P =0.778）,88.4% and 88.6% （χ2 =0.000,P =1.000）,respectively.But the occurrence rate of group B ＆#39; oral mucosa reaction （χ2 =4.295,P =0.038） and gastrointestinal reaction （χ2 =4.482,P =0.028） were higher than that of group A.Conclusion Treated with cisplatin in advanced nasopharyngeal carcinoma after radical radiotherapy combined with docetaxel is similar,and the side effect is low,the tolerance of patients is good,curative effect is satisfied.

关 键 词：鼻咽肿瘤 顺铂 多西他赛 放射疗法 

分 类 号：R739.63[医药卫生—肿瘤]