乳源性小肽的抗氧化功能研究  

Antioxidant ability of milk-derived peptide in d-galactose induced aging model

作　　者：金赢凯[1] 占东升 梁世排 徐海红[1] 高扬[1] 胡亚菁 沈鹏[1] 张少辉[1,3] 

机构地区：[1]上海交通大学农业与生物学院,上海200240 [2]浙江熊猫乳业集团股份有限公司,浙江温州325800 [3]上海交通大学陆伯勋食品安全研究中心,上海200240

出　　处：《中国乳品工业》2015年第5期4-7,共4页China Dairy Industry

摘　　要：采用D-gal致衰老动物模型,分别从组织结构、抗氧化生理生化指标以及血清细胞因子的变化情况来研究乳源小肽LPLP对受试小鼠的抗氧化能力和抗衰老能力的影响;结果表明:乳源性小肽LPLP能减轻致衰老小鼠的脾脏老化现象;在抗氧化生理生化指标层面上,LPLP对小鼠的肝脏和肾脏在SOD、MDA、T-AOC等指标上有显著性的改善作用;在细胞因子层面,LPLP能显著性降低小肽灌胃组小鼠血清中炎性细胞因子IL-6与TNF-a的分泌水平。综上所述,乳源性小肽LPLP具有改善动物的抗氧化功能并能够减轻小鼠在衰老过程中发生的老化性炎症。we adopt D- gal aging model to evaluate the potential antioxidant ability and anti-aging ability of a fermented milk derived pep- tide LPLP, which includes the organization structure changing, antioxidant biochemical indexes changing and the changing of cytokines in se- rum; Results show that the milk derived peptide LPLP can reduce aging phenomenon of spleen in model group mice; LPLP has a significant effect on mice＇s liver and kidney in SOD, MDA and T - AOC index; Levels of IL-6 and TNF-ot in administrated mice has been signifi- cantly reduced compared to that of model group .In conclusion, LPLP performances an antioxidant function and can reduce the aging-in- flammation in the this animal model.

关 键 词：乳源性小肽 抗氧化 抗衰老 

分 类 号：Q516[生物学—生物化学]