论脾虚是结直肠癌能量代谢障碍与上皮间质转化的关键病机  

Discussion on Spleen-deficiency is the Key Pathogenesis of Impaired Energy Metabolism and Epithelial-mesenchymal Transition of Colorectal Cancer

作　　者：徐文娟[1] 孙学刚[1] 

机构地区：[1]中国南方医科大学,广州510515

出　　处：《中国中医基础医学杂志》2015年第5期500-502,共3页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家自然科学基金资助项目(81273621);白云区科技计划(2012-KZ-81)

摘　　要：脾虚证是结直肠癌最常见的临床证候。脾失健运呼吸链功能障碍导致低氧状态和HIF-1α表达增高,肥人脾虚产生的慢性炎症及释放细胞因子促进糖酵解,可能是结直肠癌能量代谢障碍,即瓦博格效应的主要原因。脾虚通过低氧诱导因子1α介导的能量代谢障碍促进上皮间质转化,健脾益气中药通过健脾化痰改善结直肠肿瘤细胞的慢性炎症和能量代谢障碍,从而调控肿瘤微环境,抑制EMT,改善结直肠肿瘤的生长和转移。＂ Spleen deficiency＂ is the most common syndromes of colorectal cancer （CRC）. Spleen failing to transport and transform can induce hypoxia and expression of hypoxia inducing factor 1α might lead to Warburg effect in CRC. Obese people are trends to be Spleen deficiency and produce proinflammatory cytokines to induce glycolysis. Spleen deficiency induce hypoxia inducing factor 1α （HIF-1α） mediated energy metabolic disturbance to cause epithelial- mesenchymal transition （EMT）. Spleen tonifying herbs might ameliorate chronic inflammation and impaired energy metabolism to improve tumor microenvironment of CRC and suppress EMT.

关 键 词：结直肠癌 脾虚 瓦博格效应 上皮间质转化 低氧诱导因子1Α 

分 类 号：R223.11[医药卫生—中医基础理论]