载脂蛋白E基因多态性与老年期抑郁症的关联性  

Association study of apolipoprotein E gene polymorphisms with geriatric depression

作　　者：宗小芬 胡茂林[2] 唐劲松[2] 李宗昌[2] 陈晓岗[2] 方润领[1] 

机构地区：[1]新乡医学院第二附属医院早期干预科,新乡453002 [2]中南大学湘雅二医院精神卫生研究所

出　　处：《中华行为医学与脑科学杂志》2015年第4期319-322,共4页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：基金项目：国家自然科学基金项目（81271484）

摘　　要：目的 研究载脂蛋白E基因（apolipoprotein E gene,APOE）多态性与老年期抑郁症（geriatricdepression,GD）的关联,并探讨APOE基因型与患者抑郁症状、血脂水平及认知功能之间的关系.方法 采用单核苷酸多态性（single nucleotide polymorphism,SNP）位点检测技术检测120例GD患者及120例健康对照者APOE的rs7412及rs429358两多态性位点,分出各基因型;分析两组各基因型及等位基因频率差异;分析病例组APOE多态性与患者临床及人口学资料间的关系;采用Logistic多元回归分析各一般资料、临床资料对GD认知功能的影响.结果 两组基因型及各等位基因频率均差异无统计学意义（均P＞0.05）;携带ε4基因型的患者简易智能量表总分低于非携带者[（22.38±2.22）分,（25.28±2.28）分,t=3.091,P＜0.01],而血脂水平TC（t=2.225,P＜0.05）、LDL（t=2.728,P＜0.01）高于非携带者;携带e4患者典型临床表现为阻滞（载荷0.695）和认知障碍（载荷0.902）,而非携带者突出表现在焦虑躯体化因子（载荷0.990）和体质量因子（载荷0.864）;GD认知损害的危险因子按作用大小依次为携带ε4的基因型（b′=1.097）、TC（b′=0.401）.结论 APOE可能并非GD的发病因子;携带ε4基因型的患者认知功能差,血脂水平高;不同APOE基因型患者有不同的临床表现.Objective To examine the association between the polymorphisms of apolipoprotein E gene （APOE） and geriatric depression （GD）,and then conduct an exploratory investigation to analyse whether the APOE polymorphisms would relate to the depressive syndrome severity,the cognitive function,or the level of serum lipid in patients.Methods Participants,including 120 GD patients and 120 normal controls were enrolled to detect the two single nucleotide polymorphisms of APOE,rs7412 and rs429358 using the technology of SNP site testing.The frequency differences of genotype and allele were compared between the two groups.Then the association between APOE polymorphisms and clinical or demographic data of patients were clarified.The relationship between clinical or demographic data,and the cognitive function of GD patients were investigated using the Logistic multiple regression analysis.Results The frequency of APOE genotype and allele showed no significant difference between the two groups（P〉0.05）.Patients carrying e4 allen had significantly lower total scores of Man-Machine System Engineering（（22.38±2.22） vs （25.28±2.28）,t=3.091,P〈0.01） and higher levels of TC （t=2.225,P〈 0.05） and LDL（t=2.728,P〈0.01） compared with those without ε4 allen.The specific symptoms of patients carrying e4 allen were cognitive impairment（load 0.902） and retardant factors（load 0.695）,while patients without ε4 allen had characteristic symptoms of anxiety（load 0.990） and weight factors（load 0.864）.Ranked by the effect power,the risk factors of cognitive impairment of GD patients are ε4（b′=1.097） and then TCTC （b′=0.401）.Conclusions APOE may not modulate the susceptibility to GD.Patients carrying ε4 allen have severer cognitive impairment and higher levels of serum lipid.The different genotypes may lead to different clinical symptoms.

关 键 词：老年期抑郁症 基因多态性 认知功能 血脂 

分 类 号：R749.4[医药卫生—神经病学与精神病学]