microRNA与lncRNA在抑郁症发病及治疗中的作用  

The role of microRNA and lncRNA in pathophysiology of depressive disorder

作　　者：张理义[1] 张巧丽[1] 

机构地区：[1]解放军第102医院全军心理疾病防治中心,常州213003

出　　处：《中华行为医学与脑科学杂志》2015年第4期356-359,共4页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：基金项日：南京军区医学科技创新课题（12MA002）

摘　　要：目的 microRNA （miRNA）是一类小分子非编码单链RNA,长约22个核苷酸（nt）;lncRNA是一类长度超过200 nt的非编码长链RNA,两者均可在不同层面上调控多种基因表达.本文综述了microR-NA/lncRNA与抑郁症的关系,并探讨了其对抗抑郁药药效的预测作用.方法 在2015年2～3月通过PubMed、ScienceDirect等多个数据库进行检索,以“microRNA”、“lncRNA”、“抑郁症”、“抗抑郁药物”、“生物学标记物”等检索词,用“microRNA与抑郁症”、“lncRNA与抑郁症”等检索式,通过文献追溯,收集国外1997～2014年公开发表的文献87篇,经过文献筛选,最终确定相关文献50篇.结果 miRNA、lncRNA可能参与抑郁症的病理生理过程,而miRNA在抗抑郁药物治疗过程中亦起到关键作用.以miRNA、lncRNA为代表的生物标记物与抑郁症存在关联,其对抗抑郁药药效起到预测作用.结论 miRNA与lncRNA在抑郁症的发病机制及药物治疗中发挥重要作用,miRNA在突触可塑性、应激反应易感性、神经元及神经营养因子（BDNF）生成、抗抑郁药物恢复神经功能等过程中都扮演重要角色;lncRNA在包括染色体重塑、组蛋白修饰、转录干扰与激活等过程中发挥调控作用.Objective microRNA （miRNA） are a class of small molecule non-coding single-stranded RNA,and about 22 nucleotides （nt）;lncRNA is a class of non-coding RNA long chain that longer than 200 nt,both of miRNA and lncRNA can regulate many kinds of genes＆#39; expression under different levels.This paper reviewed relationship of miRNA/lncRNAexpression level and depressive disorder,and to explore theirpredictive effects of antidepressantpharmacodynamics.Methods By retrieving literature in database of PubMed,ScienceDirect in February,March 2015 using microRNA,lncRNA,depressive disorder,antidepressants,biological markers as searching words and （depressive disorder OR antidepressant） and all field：miRNA/lncRNA as index strategy,based on literature retrieving,we acquired 87 articles and totally enrolled 50 close related articles as reviewing materials by literature screening.Results Existing studies suggested that miRNA and lncRNA may be involved in pathophysiology of depression,and miRNA may play a key role in antidepressant treatment.miRNA or lncRNA as biomarkers may be associated with depression.Conclusion Researches on miRNA or lncRNA shed light on pathological mechanism of depressive disorder and antidepressantpharmacodynamics.miRNAcan function in synaptic plasticity,sensitivity of stress reaction,production of neuron and brain-derived neurotropic factor,recovery of neural function after antidepressant treatment,while lncRNA has regulatory effects on chromosome remodeling,histone modification,Transcriptioninterference andactivation.

关 键 词：抑郁症 抗抑郁药物 生物学标记物 

分 类 号：R749.4[医药卫生—神经病学与精神病学]