碘与甲状腺常见疾病相关性研究  

Relationship between the common diseases of thyroid and iodine

作　　者：章阳[1,2] 解磐磐[2] 丁洁[3] 崔兆清[2] 孙善平[2] 周长鑫[2] 刘保国[2] 姜宝法[1] 

机构地区：[1]山东大学公共卫生学院流行病与卫生统计学系,山东济南250012 [2]山东省聊城市人民医院乳腺甲状腺外科,山东聊城252000 [3]山东省聊城市人民医院中心实验室,山东聊城252000

出　　处：《中华肿瘤防治杂志》2015年第9期687-691,共5页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的探讨甲状腺常见疾病类型与甲状腺组织含碘量(组织碘)、尿碘的关系,并分析甲状腺疾病组织碘、尿碘相关性及组织碘、尿碘与甲状腺功能指标之间的关系。方法 2011-01-01-2012-08-30聊城市人民医院收治甲状腺手术标本108例,其中甲状腺乳头状癌44例,良性甲状腺疾病64例(包括结节性甲状腺肿45例、甲状腺滤泡性肿瘤11例和桥本甲状腺炎8例),测定甲状腺组织碘、尿碘、血清游离三碘甲状腺原氨酸(free triiodothyronine,FT3)、游离四碘甲状腺原氨酸(free tetraiodothyronine,FT4)和促甲状腺激素(thyroid stimulating hormone,TSH)含量,并对所得指标进行分析。结果甲状腺乳头状癌组组织碘的均值为(296.48±82.28)μg/L,明显高于良性疾病组的(154.92±77.77)μg/L,且甲状腺乳头状癌组尿碘的均值为(248.41±92.05)μg/L,也明显高于良性疾病组的(141.02±81.95)μg/L。在良性疾病组中,结节性甲状腺肿组组织碘的均值为(168.96±79.46)μg/L,显著高于滤泡性肿瘤组的(98.64±50.70)μg/L,组织碘与尿碘存在一致性,组织碘、尿碘与甲状腺功能指标间无相关性,P>0.05。结论甲状腺良恶性疾病间的组织碘、尿碘存在显著差异,说明碘参与了甲状腺恶性疾病的发生,且组织碘与其相对应的疾病人群中尿碘含量呈一致性表现,提示尿碘检测能够反映甲状腺组织含碘量,可用于甲状腺疾病性质的筛查,有助于个体化补碘的指导。OBJECTIVE To investigate the relationship between common types of thyroid diseases and the thyroid＇s iodine and urine iodine contents,and to analyze the association between urinary iodine,thyroid＇s iodine contents and thyroid function,respectively.METHODS The levels of tissue and urinary iodine contents,serum concentrations of free triiodothyronine（FT3）,free thyroxin（FT4）and thyroid-stimulating hormone（TSH）were checked in four types of thyroid diseases including thyroid papillary carcinoma,nodular goiter,thyroid follicular tumor and hashimoto thyroiditis.The data were analyzed by SPSS 20.0.RESULTS The mean value of tissue iodine content was significantly higher in thyroid papillary carcinoma（296.48±82.28）μg/L than that in benign diseases（154.92±77.77）μg/L.The mean value of urine iodine was significantly higher in thyroid papillary carcinoma（248.41±92.05）μg/L than that in benign diseases（141.02±81.95）μg/L.In the benign diseases groups,the mean value of tissue iodine content was significantly higher in nodular goiter（168.96±79.46）μg/L than that in thyroid follicular tumor（98.64±50.70）μg/L.In all groups,there were positively correlation between tissue iodine content and urinary iodine.No significant correlation was observed between tissue iodine content,urine iodine and the index of thyroid function（P〉0.05）.CONCLUSIONS In Liaocheng area,the significant difference of the thyroid＇s iodine and urine iodine contents between malignant thyroid disease and benign thyroid disease shows that iodine plays some part in the pathogenesis of thyroid malignant disease.The consistency between urine iodine and thyroid＇s iodine contents indicates that the urinary iodine examination could predict the thyroid tissue iodine content.This particular indicator could be useful for screening thyroid disease,and would be helpful for investigating iodine nutrition status of individual person.

关 键 词：甲状腺疾病 组织含碘量 尿碘 甲状腺功能 

分 类 号：R736.1[医药卫生—肿瘤]