小肠细菌过度生长对非酒精性肝病肝纤维化指标的影响  

Influence of small intestinal bacterial overgrowth on indicators of hepatic fibrosis in non-alcoholic liver disease

作　　者：李伟伟[1] 韩红波[2] 

机构地区：[1]河南科技大学第二附属医院消化内科,洛阳471000 [2]河南科技大学医学院病理生理教研室,洛阳471000

出　　处：《中国当代医药》2015年第14期35-37,共3页China Modern Medicine

摘　　要：目的探讨非酒精性脂肪性肝病（NAFLD）与小肠细菌过度生长（SIBO）的关系,进一步了解NAFLD患者SIBO的发生率及肠源性内毒素血症（IETM）对肿瘤坏死因子-α（TNF-α）、肝纤维化水平的影响,评价其在NAFLD发生发展过程中的作用。方法选择2013年2-8月本院经B超及病史诊断为NAFLD患者32例,行乳果糖氢呼气试验（LHBT）检测,根据LHBT结果将32例NAFLD患者分为SIBO阳性组和SIBO阴性组。对两组IETM、TNF-α、肝纤维化指标进行检测。结果 IETM、TNF-α在SIBO阳性组和SIBO阴性组比较差异均有统计学意义;SIBO阳性组TNF-α、肝纤维化指标有逐渐增高的趋势,两者均与IETM呈正相关。结论 SIBO和内毒素血症等机制促进NAFLD的发生和发展。Objective To explore the relationship between non-alcoholic fatty liver disease （NAFLD） and small intesti-nal bacterial overgrowth （SIBO） and further get known the incidence of SIBO in NAFLD patients and influences of in-testinal endotoxemia （IETM） on tumor necrosis factor-α （TNF-α） and liver fibrosis aiming at evaluating its role in the occurrence and development of NAFLD. Methods 32 patients diagnosed as NAFLD by B ultrasound and medical histo-ry in our hospital from February to August 2013 were selected.They were performed with lactulose hydrogen breath test （LHBT）.According to LHBT outcomes,these participants were divided into SIBO positive group and SIBO negative group.Indicators of IETM,TNF-α,and liver fibrosis was tested respectively. Results There were statistical differences in IETM and TNF-α after comparisons between two groups.In SIBO positive group,TNF-α and liver fibrosis gradually in-creased,which both had positive correlations with IETM. Conclusion Mechanisms of SIBO and IETM both promote the occurrence and development of NAFLD.

关 键 词：非酒精性脂肪性肝病 呼吸试验 小肠细菌过度生长 肝纤维化 

分 类 号：R575[医药卫生—消化系统]