亚甲基四氢叶酸还原酶基因C677T、A1298C多态性与胃癌的关系  

Relationship between the methylenetetrahydrofolate reductase C677T, A1298C genetic polymorphisms and gastric cancer

作　　者：徐昌隆[1] 王建嶂[1] 郑波[1] 曹曙光[1] 吴昊[1] 薛战雄[1] 

机构地区：[1]温州医科大学附属第二医院消化内科,浙江温州325027

出　　处：《温州医学院学报》2015年第5期338-341,共4页Journal of Wenzhou Medical College

基　　金：温州市科技计划资助项目(Y20110132)

摘　　要：目的：探讨亚甲基四氢叶酸还原酶（MTHFR）C677T和A1298C基因多态性与浙江汉族人群胃癌的关系。方法：采用聚合酶链反应-限制性片段长度多态性（PCR-RELP）技术,检测112例胃癌患者和218例正常对照者的MTHFR C677T及A1298C基因多态性分布差异。结果：MTHFR C677T的突变等位基因T及变异基因型（CT＋TT）频率在胃癌组和对照组之间均无统计学差异（34.82%vs 32.57%和53.57%vs 52.75%,均P〉0.05）。胃癌组MTHFR A1298C突变等位基因C明显高于对照组,差异有统计学意义（21.43%vs 12.39%,P=0.006,OR=1.929,95%CI：1.325~2.873）,而2组间突变基因型（AC＋CC）频率差异无统计学意义（32.15%vs36.24%,P〉0.05）。结论：浙江汉族人群MTHFR A1298C突变等位基因C可能与胃癌的易感性有关。ective： To evaluate the association between methylenetetrahydrofolate reductase（MTHFR） C677 T, A1298 C genetic polymorphisms and gastric cancer in Zhejiang Han nationality population. Methods： Select 112 cases of patients with gastric cancer, choose health check-up 218 cases as controls. The genetic polymorphisms of MTHFR（C677T and A1298C） were detected by PCR-RELP method. Results： There were no significant discrepancies of the mutational allele T and variant genotype（CT＋TT） frequencies in the MTHFR C677 T gene between the gastric cancer patients and the controls（34.82% vs 32.57% and 53.57% vs 52.75%, respectively, all P〉0.05）. The frequency of mutational allele C in MTHFR A1298 C gene was significantly higher in gastric cancer patients than that in the controls（21.43% vs 12.39%, P=0.006, OR=1.929, 95%CI： 1.325~2.873）. However, there were no significant discrepancies of the variant genotype frequencies（AC＋CC） between the two groups（32.15% vs 36.24%, P〉0.05）. Conclusion： The mutational allele C in MTHFR A1298 C gene may be associated with the susceptibility to gastric cancer in Zhejiang Han nationality population.

关 键 词：亚甲基四氢叶酸还原酶 基因多态性 胃肿瘤 

分 类 号：R735.2[医药卫生—肿瘤]