Meta-analysis of C242T polymorphism in CYBA genes: risk of acute coronary syndrome is lower in Asians but not in Caucasians  

CYBA基因C242T基因多态性的荟萃分析:亚洲人群急性冠脉综合征风险降低而高加索人群没有（英文）

作　　者：Po HU Ming-yuan HUANG Xin-yang HU Xiao-jie XIE Mei-xiang XIANG Xian-bao LIU Jian-an WANG 

机构地区：[1]Key Laboratory for Diagnosis and Treatment of Cardiovascular Disease of Zhejiang Province, the Second Affiliated Hospital,School of Medicine, Zhejiang University [2]Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2015年第5期370-379,共10页浙江大学学报（英文版）B辑（生物医学与生物技术）

摘　　要：Background：A lot of studies have demonstrated that C242T polymorphism in CYBA genes may play an important role in the pathological process of acute coronary syndrome （ACS）. However, the results are not consistent. To further evaluate this debate, we performed a meta-analysis to determine the relationship between C242T poly-morphism and ACS. Methods and results：We screened PubMed/MEDLINE, EBSCIO, and EMBASE research reports until Mar. 2014 and extracted data from 10 studies involving 6102 ACS patients and 8669 controls. Subgroup analysis by ethnicity documented a significant decreased risk of ACS for C242T polymorphism in the Asian population under al elic comparison （odd ratio （OR） 0.73;95%confidence intervals （CI） 0.64–0.83）, dominant model （OR 0.71;95%CI 0.62–0.82）, and homozygote comparison （OR 0.57;95%CI 0.35–0.92）. However, in the overal population and es-pecial y with Caucasians, no significant association was uncovered. Further meta-regression analysis revealed that the heterogeneity among studies was largely attributed to ethnicity. No publication bias was detected through a funnel plot and an Egger’s linear regression test. Conclusions： Taken together, our results suggest that the C242T poly-morphism might be a protective factor against developing ACS in the Asian population. Further researches wil be needed to identify the confounding factors which modified the protective effect of T al ele among Caucasians.目的:探讨CYBA基因C242T基因多态性与急性冠脉综合征的关系。创新点:提出了C242T基因多态性对急性冠脉综合征的影响存在种族差异。方法:荟萃分析了C242T基因多态性与急性冠脉综合征的关系。结论:对于亚洲人群而言,C242T基因多态性为急性冠脉综合征的保护因素。

关 键 词：CYBA C242T polymorphism Acute coronary syndrome 

分 类 号：R541.4[医药卫生—心血管疾病]